A Selective Intramolecular 5-exo-dig or 6-endo-dig Cyclization en Route to 2-Furanone or 2-Pyrone Containing Tricyclic Scaffolds

[Image: see text] Ringfused bicyclic 2-pyridones exhibit interesting biological properties against pili assembly in uropathogenic Escherichia coli (Pinkner, J. S. et al. Proc. Natl. Acad. Sci. U. S. A.2006, 103, 17897–17902; Åberg, V. et al. Org. Biomol. Chem.2007, 5, 1827–1834) as well as curli for...

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Detalles Bibliográficos
Autores principales: Bengtsson, Christoffer, Almqvist, Fredrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225090/
https://www.ncbi.nlm.nih.gov/pubmed/22008034
http://dx.doi.org/10.1021/jo201952p
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author Bengtsson, Christoffer
Almqvist, Fredrik
author_facet Bengtsson, Christoffer
Almqvist, Fredrik
author_sort Bengtsson, Christoffer
collection PubMed
description [Image: see text] Ringfused bicyclic 2-pyridones exhibit interesting biological properties against pili assembly in uropathogenic Escherichia coli (Pinkner, J. S. et al. Proc. Natl. Acad. Sci. U. S. A.2006, 103, 17897–17902; Åberg, V. et al. Org. Biomol. Chem.2007, 5, 1827–1834) as well as curli formation (Cegelski, L. et al. Nat. Chem. Biol.2009, 5, 913–919). In the search for new ring-fused central fragments, highly selective synthetic routes to the 2-furanone or 2-pyrone containing tricyclic scaffolds 1 and 2 have been developed.
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spelling pubmed-32250902011-11-28 A Selective Intramolecular 5-exo-dig or 6-endo-dig Cyclization en Route to 2-Furanone or 2-Pyrone Containing Tricyclic Scaffolds Bengtsson, Christoffer Almqvist, Fredrik J Org Chem [Image: see text] Ringfused bicyclic 2-pyridones exhibit interesting biological properties against pili assembly in uropathogenic Escherichia coli (Pinkner, J. S. et al. Proc. Natl. Acad. Sci. U. S. A.2006, 103, 17897–17902; Åberg, V. et al. Org. Biomol. Chem.2007, 5, 1827–1834) as well as curli formation (Cegelski, L. et al. Nat. Chem. Biol.2009, 5, 913–919). In the search for new ring-fused central fragments, highly selective synthetic routes to the 2-furanone or 2-pyrone containing tricyclic scaffolds 1 and 2 have been developed. American Chemical Society 2011-10-18 2011-12-02 /pmc/articles/PMC3225090/ /pubmed/22008034 http://dx.doi.org/10.1021/jo201952p Text en Copyright © 2011 American Chemical Society http://pubs.acs.org This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org.
spellingShingle Bengtsson, Christoffer
Almqvist, Fredrik
A Selective Intramolecular 5-exo-dig or 6-endo-dig Cyclization en Route to 2-Furanone or 2-Pyrone Containing Tricyclic Scaffolds
title A Selective Intramolecular 5-exo-dig or 6-endo-dig Cyclization en Route to 2-Furanone or 2-Pyrone Containing Tricyclic Scaffolds
title_full A Selective Intramolecular 5-exo-dig or 6-endo-dig Cyclization en Route to 2-Furanone or 2-Pyrone Containing Tricyclic Scaffolds
title_fullStr A Selective Intramolecular 5-exo-dig or 6-endo-dig Cyclization en Route to 2-Furanone or 2-Pyrone Containing Tricyclic Scaffolds
title_full_unstemmed A Selective Intramolecular 5-exo-dig or 6-endo-dig Cyclization en Route to 2-Furanone or 2-Pyrone Containing Tricyclic Scaffolds
title_short A Selective Intramolecular 5-exo-dig or 6-endo-dig Cyclization en Route to 2-Furanone or 2-Pyrone Containing Tricyclic Scaffolds
title_sort selective intramolecular 5-exo-dig or 6-endo-dig cyclization en route to 2-furanone or 2-pyrone containing tricyclic scaffolds
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225090/
https://www.ncbi.nlm.nih.gov/pubmed/22008034
http://dx.doi.org/10.1021/jo201952p
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