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Exploration of sex differences in Rhes effects in dopamine mediated behaviors

Studies have shown that Ras homolog enriched in striatum (Rhes) proteins are highly expressed in areas of the central nervous system that have high dopaminergic innervation. In this study, we used Rhes mutant mice (Wild type, Rhes KO, Rhes Heterozygous) of both sexes to explore differences in the ef...

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Detalles Bibliográficos
Autores principales: Quintero, Gabriel C, Spano, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225344/
https://www.ncbi.nlm.nih.gov/pubmed/22128255
http://dx.doi.org/10.2147/NDT.S25888
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author Quintero, Gabriel C
Spano, Daniela
author_facet Quintero, Gabriel C
Spano, Daniela
author_sort Quintero, Gabriel C
collection PubMed
description Studies have shown that Ras homolog enriched in striatum (Rhes) proteins are highly expressed in areas of the central nervous system that have high dopaminergic innervation. In this study, we used Rhes mutant mice (Wild type, Rhes KO, Rhes Heterozygous) of both sexes to explore differences in the effects of Rhes protein levels in basal levels of activity, anxiety, and stereotypy, in relation to sex. Adult male and female mice were evaluated in an open field test for measuring basal levels of activity and anxiety for 5 consecutive days, and they were tested in the apomorphine-induced stereotypy paradigm. Rhes protein levels affected basal levels of activity but it was not found to be related to sex differences. Moreover, a decrease in Rhes protein levels was linked to a nonsignificant anxiolytic effect, mainly in female mice. Finally, a decrease in Rhes protein levels does not affect dopamine D(1) and D(2) receptor (D(1)/D(2)) synergism in female or male mice. Together, these results suggest that Rhes protein levels affect locomotion activity, and have an influence in anxiety depending on sex; Rhes protein levels do not affect D(1)/D(2) synergism in both sexes.
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spelling pubmed-32253442011-11-29 Exploration of sex differences in Rhes effects in dopamine mediated behaviors Quintero, Gabriel C Spano, Daniela Neuropsychiatr Dis Treat Original Research Studies have shown that Ras homolog enriched in striatum (Rhes) proteins are highly expressed in areas of the central nervous system that have high dopaminergic innervation. In this study, we used Rhes mutant mice (Wild type, Rhes KO, Rhes Heterozygous) of both sexes to explore differences in the effects of Rhes protein levels in basal levels of activity, anxiety, and stereotypy, in relation to sex. Adult male and female mice were evaluated in an open field test for measuring basal levels of activity and anxiety for 5 consecutive days, and they were tested in the apomorphine-induced stereotypy paradigm. Rhes protein levels affected basal levels of activity but it was not found to be related to sex differences. Moreover, a decrease in Rhes protein levels was linked to a nonsignificant anxiolytic effect, mainly in female mice. Finally, a decrease in Rhes protein levels does not affect dopamine D(1) and D(2) receptor (D(1)/D(2)) synergism in female or male mice. Together, these results suggest that Rhes protein levels affect locomotion activity, and have an influence in anxiety depending on sex; Rhes protein levels do not affect D(1)/D(2) synergism in both sexes. Dove Medical Press 2011 2011-11-17 /pmc/articles/PMC3225344/ /pubmed/22128255 http://dx.doi.org/10.2147/NDT.S25888 Text en © 2011 Quintero and Spano, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Quintero, Gabriel C
Spano, Daniela
Exploration of sex differences in Rhes effects in dopamine mediated behaviors
title Exploration of sex differences in Rhes effects in dopamine mediated behaviors
title_full Exploration of sex differences in Rhes effects in dopamine mediated behaviors
title_fullStr Exploration of sex differences in Rhes effects in dopamine mediated behaviors
title_full_unstemmed Exploration of sex differences in Rhes effects in dopamine mediated behaviors
title_short Exploration of sex differences in Rhes effects in dopamine mediated behaviors
title_sort exploration of sex differences in rhes effects in dopamine mediated behaviors
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225344/
https://www.ncbi.nlm.nih.gov/pubmed/22128255
http://dx.doi.org/10.2147/NDT.S25888
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