MUC1-C Oncoprotein Regulates Glycolysis and Pyruvate Kinase m2 Activity in Cancer Cells

Aerobic glycolysis in cancer cells is regulated by multiple effectors that include Akt and pyruvate kinase M2 (PKM2). Mucin 1 (MUC1) is a heterodimeric glycoprotein that is aberrantly overexpressed by human breast and other carcinomas. Here we show that transformation of rat fibroblasts by the oncog...

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Detalles Bibliográficos
Autores principales: Kosugi, Michio, Ahmad, Rehan, Alam, Maroof, Uchida, Yasumitsu, Kufe, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225393/
https://www.ncbi.nlm.nih.gov/pubmed/22140559
http://dx.doi.org/10.1371/journal.pone.0028234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225393/
https://www.ncbi.nlm.nih.gov/pubmed/22140559
http://dx.doi.org/10.1371/journal.pone.0028234

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