Frajunolides L–O, Four New 8-Hydroxybriarane Diterpenoids from the Gorgonian Junceella fragilis

Four new 8-hydroxybriarane diterpenoids, frajunolides L–O (1–4), were isolated from the Taiwanese gorgonian Junceella fragilis. The structures of compounds 1–4 were elucidated based on spectroscopic analysis, especially 2D NMR ((1)H-(1)H COSY, HSQC, HMBC and NOESY) and HRMS. Compounds 1 and 4 showed...

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Detalles Bibliográficos
Autores principales: Liaw, Chia-Ching, Kuo, Yao-Haur, Lin, Yun-Sheng, Hwang, Tsong-Long, Shen, Ya-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225929/
https://www.ncbi.nlm.nih.gov/pubmed/22131952
http://dx.doi.org/10.3390/md9091477
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author Liaw, Chia-Ching
Kuo, Yao-Haur
Lin, Yun-Sheng
Hwang, Tsong-Long
Shen, Ya-Ching
author_facet Liaw, Chia-Ching
Kuo, Yao-Haur
Lin, Yun-Sheng
Hwang, Tsong-Long
Shen, Ya-Ching
author_sort Liaw, Chia-Ching
collection PubMed
description Four new 8-hydroxybriarane diterpenoids, frajunolides L–O (1–4), were isolated from the Taiwanese gorgonian Junceella fragilis. The structures of compounds 1–4 were elucidated based on spectroscopic analysis, especially 2D NMR ((1)H-(1)H COSY, HSQC, HMBC and NOESY) and HRMS. Compounds 1 and 4 showed weak anti-inflammatory activity as tested by superoxide anion generation and elastase release by human neutrophil in response to fMLP/CB. Compound 3 showed selective inhibition on elastase release in vitro.
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spelling pubmed-32259292011-11-30 Frajunolides L–O, Four New 8-Hydroxybriarane Diterpenoids from the Gorgonian Junceella fragilis Liaw, Chia-Ching Kuo, Yao-Haur Lin, Yun-Sheng Hwang, Tsong-Long Shen, Ya-Ching Mar Drugs Article Four new 8-hydroxybriarane diterpenoids, frajunolides L–O (1–4), were isolated from the Taiwanese gorgonian Junceella fragilis. The structures of compounds 1–4 were elucidated based on spectroscopic analysis, especially 2D NMR ((1)H-(1)H COSY, HSQC, HMBC and NOESY) and HRMS. Compounds 1 and 4 showed weak anti-inflammatory activity as tested by superoxide anion generation and elastase release by human neutrophil in response to fMLP/CB. Compound 3 showed selective inhibition on elastase release in vitro. Molecular Diversity Preservation International 2011-09-02 /pmc/articles/PMC3225929/ /pubmed/22131952 http://dx.doi.org/10.3390/md9091477 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Liaw, Chia-Ching
Kuo, Yao-Haur
Lin, Yun-Sheng
Hwang, Tsong-Long
Shen, Ya-Ching
Frajunolides L–O, Four New 8-Hydroxybriarane Diterpenoids from the Gorgonian Junceella fragilis
title Frajunolides L–O, Four New 8-Hydroxybriarane Diterpenoids from the Gorgonian Junceella fragilis
title_full Frajunolides L–O, Four New 8-Hydroxybriarane Diterpenoids from the Gorgonian Junceella fragilis
title_fullStr Frajunolides L–O, Four New 8-Hydroxybriarane Diterpenoids from the Gorgonian Junceella fragilis
title_full_unstemmed Frajunolides L–O, Four New 8-Hydroxybriarane Diterpenoids from the Gorgonian Junceella fragilis
title_short Frajunolides L–O, Four New 8-Hydroxybriarane Diterpenoids from the Gorgonian Junceella fragilis
title_sort frajunolides l–o, four new 8-hydroxybriarane diterpenoids from the gorgonian junceella fragilis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225929/
https://www.ncbi.nlm.nih.gov/pubmed/22131952
http://dx.doi.org/10.3390/md9091477
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