A New Anthracene Derivative from Marine Streptomyces sp. W007 Exhibiting Highly and Selectively Cytotoxic Activities

A new anthracene derivative, 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3, 4-tetrahydro-benz[α]anthracene, was isolated from the marine strain Streptomyces sp. W007, and its structure was established by spectroscopic analysis including mass spectra, 1D- and 2D-NMR ((1)H–(1)H COSY, HMBC, HSQC and NOESY)...

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Autores principales: Zhang, Hongyu, Wang, Hongpeng, Cui, Hongli, Li, Zonggang, Xie, Zeping, Pu, Yang, Li, Fuchao, Qin, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225931/
https://www.ncbi.nlm.nih.gov/pubmed/22131954
http://dx.doi.org/10.3390/md9091502
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author Zhang, Hongyu
Wang, Hongpeng
Cui, Hongli
Li, Zonggang
Xie, Zeping
Pu, Yang
Li, Fuchao
Qin, Song
author_facet Zhang, Hongyu
Wang, Hongpeng
Cui, Hongli
Li, Zonggang
Xie, Zeping
Pu, Yang
Li, Fuchao
Qin, Song
author_sort Zhang, Hongyu
collection PubMed
description A new anthracene derivative, 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3, 4-tetrahydro-benz[α]anthracene, was isolated from the marine strain Streptomyces sp. W007, and its structure was established by spectroscopic analysis including mass spectra, 1D- and 2D-NMR ((1)H–(1)H COSY, HMBC, HSQC and NOESY) experiments. 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[α]anthracene showed cytotoxicity against human lung adenocarcinoma cell line A549.
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spelling pubmed-32259312011-11-30 A New Anthracene Derivative from Marine Streptomyces sp. W007 Exhibiting Highly and Selectively Cytotoxic Activities Zhang, Hongyu Wang, Hongpeng Cui, Hongli Li, Zonggang Xie, Zeping Pu, Yang Li, Fuchao Qin, Song Mar Drugs Article A new anthracene derivative, 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3, 4-tetrahydro-benz[α]anthracene, was isolated from the marine strain Streptomyces sp. W007, and its structure was established by spectroscopic analysis including mass spectra, 1D- and 2D-NMR ((1)H–(1)H COSY, HMBC, HSQC and NOESY) experiments. 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[α]anthracene showed cytotoxicity against human lung adenocarcinoma cell line A549. Molecular Diversity Preservation International 2011-09-09 /pmc/articles/PMC3225931/ /pubmed/22131954 http://dx.doi.org/10.3390/md9091502 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zhang, Hongyu
Wang, Hongpeng
Cui, Hongli
Li, Zonggang
Xie, Zeping
Pu, Yang
Li, Fuchao
Qin, Song
A New Anthracene Derivative from Marine Streptomyces sp. W007 Exhibiting Highly and Selectively Cytotoxic Activities
title A New Anthracene Derivative from Marine Streptomyces sp. W007 Exhibiting Highly and Selectively Cytotoxic Activities
title_full A New Anthracene Derivative from Marine Streptomyces sp. W007 Exhibiting Highly and Selectively Cytotoxic Activities
title_fullStr A New Anthracene Derivative from Marine Streptomyces sp. W007 Exhibiting Highly and Selectively Cytotoxic Activities
title_full_unstemmed A New Anthracene Derivative from Marine Streptomyces sp. W007 Exhibiting Highly and Selectively Cytotoxic Activities
title_short A New Anthracene Derivative from Marine Streptomyces sp. W007 Exhibiting Highly and Selectively Cytotoxic Activities
title_sort new anthracene derivative from marine streptomyces sp. w007 exhibiting highly and selectively cytotoxic activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225931/
https://www.ncbi.nlm.nih.gov/pubmed/22131954
http://dx.doi.org/10.3390/md9091502
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