Nardosinane-Type Sesquiterpenoids from the Formosan Soft Coral Paralemnalia thyrsoides

Five new nardosinane-type sesquiterpenoids, paralemnolins Q–U (1–5), along with three known compounds (6–8), were isolated from the Formosan soft coral Paralemnalia thyrsoides. The structures of new metabolites were elucidated on the basis of extensive spectroscopic methods, and the absolute configu...

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Autores principales: Huang, Chiung-Yao, Su, Jui-Hsin, Chen, Bo-Wei, Wen, Zhi-Hong, Hsu, Chi-Hsin, Dai, Chang-Feng, Sheu, Jyh-Horng, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225934/
https://www.ncbi.nlm.nih.gov/pubmed/22131957
http://dx.doi.org/10.3390/md9091543
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author Huang, Chiung-Yao
Su, Jui-Hsin
Chen, Bo-Wei
Wen, Zhi-Hong
Hsu, Chi-Hsin
Dai, Chang-Feng
Sheu, Jyh-Horng
Sung, Ping-Jyun
author_facet Huang, Chiung-Yao
Su, Jui-Hsin
Chen, Bo-Wei
Wen, Zhi-Hong
Hsu, Chi-Hsin
Dai, Chang-Feng
Sheu, Jyh-Horng
Sung, Ping-Jyun
author_sort Huang, Chiung-Yao
collection PubMed
description Five new nardosinane-type sesquiterpenoids, paralemnolins Q–U (1–5), along with three known compounds (6–8), were isolated from the Formosan soft coral Paralemnalia thyrsoides. The structures of new metabolites were elucidated on the basis of extensive spectroscopic methods, and the absolute configuration of 1 was determined by the application of Mosher’s method on 1. Among these metabolites, 1 and 3 are rarely found nardosinane-type sesquiterpenoids, possessing novel polycyclic structures. Compounds 1, 3, 6 and 7 were found to possess neuroprotective activity.
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spelling pubmed-32259342011-11-30 Nardosinane-Type Sesquiterpenoids from the Formosan Soft Coral Paralemnalia thyrsoides Huang, Chiung-Yao Su, Jui-Hsin Chen, Bo-Wei Wen, Zhi-Hong Hsu, Chi-Hsin Dai, Chang-Feng Sheu, Jyh-Horng Sung, Ping-Jyun Mar Drugs Article Five new nardosinane-type sesquiterpenoids, paralemnolins Q–U (1–5), along with three known compounds (6–8), were isolated from the Formosan soft coral Paralemnalia thyrsoides. The structures of new metabolites were elucidated on the basis of extensive spectroscopic methods, and the absolute configuration of 1 was determined by the application of Mosher’s method on 1. Among these metabolites, 1 and 3 are rarely found nardosinane-type sesquiterpenoids, possessing novel polycyclic structures. Compounds 1, 3, 6 and 7 were found to possess neuroprotective activity. Molecular Diversity Preservation International 2011-09-16 /pmc/articles/PMC3225934/ /pubmed/22131957 http://dx.doi.org/10.3390/md9091543 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Huang, Chiung-Yao
Su, Jui-Hsin
Chen, Bo-Wei
Wen, Zhi-Hong
Hsu, Chi-Hsin
Dai, Chang-Feng
Sheu, Jyh-Horng
Sung, Ping-Jyun
Nardosinane-Type Sesquiterpenoids from the Formosan Soft Coral Paralemnalia thyrsoides
title Nardosinane-Type Sesquiterpenoids from the Formosan Soft Coral Paralemnalia thyrsoides
title_full Nardosinane-Type Sesquiterpenoids from the Formosan Soft Coral Paralemnalia thyrsoides
title_fullStr Nardosinane-Type Sesquiterpenoids from the Formosan Soft Coral Paralemnalia thyrsoides
title_full_unstemmed Nardosinane-Type Sesquiterpenoids from the Formosan Soft Coral Paralemnalia thyrsoides
title_short Nardosinane-Type Sesquiterpenoids from the Formosan Soft Coral Paralemnalia thyrsoides
title_sort nardosinane-type sesquiterpenoids from the formosan soft coral paralemnalia thyrsoides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225934/
https://www.ncbi.nlm.nih.gov/pubmed/22131957
http://dx.doi.org/10.3390/md9091543
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