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Controlled Release of Diclofenac from Matrix Polymer of Chitosan and Oxidized Konjac Glucomannan

The controlled release of diclofenac sodium (DFNa) from a chitosan-oxidized konjac glucomannan (CTS-OKG) polymer film was studied. Konjac glucomannan (KGM) was initially oxidized by sodium periodate and then cross-linked to CTS via imine bonds (–C=N–) to form the new CTS-OKG copolymer. The DFNa load...

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Autores principales: Korkiatithaweechai, Suphat, Umsarika, Pornpusadee, Praphairaksit, Narong, Muangsin, Nongnuj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225940/
https://www.ncbi.nlm.nih.gov/pubmed/22131963
http://dx.doi.org/10.3390/md9091649
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author Korkiatithaweechai, Suphat
Umsarika, Pornpusadee
Praphairaksit, Narong
Muangsin, Nongnuj
author_facet Korkiatithaweechai, Suphat
Umsarika, Pornpusadee
Praphairaksit, Narong
Muangsin, Nongnuj
author_sort Korkiatithaweechai, Suphat
collection PubMed
description The controlled release of diclofenac sodium (DFNa) from a chitosan-oxidized konjac glucomannan (CTS-OKG) polymer film was studied. Konjac glucomannan (KGM) was initially oxidized by sodium periodate and then cross-linked to CTS via imine bonds (–C=N–) to form the new CTS-OKG copolymer. The DFNa loaded CTS-OKG polymers were characterized by Fourier transformed infrared spectroscopy (FT-IR) and X-ray diffractometry (XRD). Finally, the release profiles of DFNa from the CTS-OKG polymer matrices were evaluated in a simulated gastrointestinal fluid system comprised of two hours in simulated gastric fluid (SGF; pH 1.2) followed by 24 h in simulated intestinal fluid (SIF; pH 7.4). A 1:2:1 (w/w/w) ratio of CTS:OKG:DFNa prepared at room temperature for 3 hours gave the highest % encapsulation efficiency (EE) of 95.6 ± 0.6 and resulted in a minimal release of DFNa (<1% over 2 h) in SGF (pH 1.2) and a significantly improved sustained release in SIF (pH 7.4) with ~6% and 19% release over 8 and 24 h, respectively), some 15- and five-fold lower than that of the two commercial DFNa preparations, Diclosian and Voltaren. This formulation may be used for further study as a long term intestine controlled release drug model (at least 3 days).
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spelling pubmed-32259402011-11-30 Controlled Release of Diclofenac from Matrix Polymer of Chitosan and Oxidized Konjac Glucomannan Korkiatithaweechai, Suphat Umsarika, Pornpusadee Praphairaksit, Narong Muangsin, Nongnuj Mar Drugs Article The controlled release of diclofenac sodium (DFNa) from a chitosan-oxidized konjac glucomannan (CTS-OKG) polymer film was studied. Konjac glucomannan (KGM) was initially oxidized by sodium periodate and then cross-linked to CTS via imine bonds (–C=N–) to form the new CTS-OKG copolymer. The DFNa loaded CTS-OKG polymers were characterized by Fourier transformed infrared spectroscopy (FT-IR) and X-ray diffractometry (XRD). Finally, the release profiles of DFNa from the CTS-OKG polymer matrices were evaluated in a simulated gastrointestinal fluid system comprised of two hours in simulated gastric fluid (SGF; pH 1.2) followed by 24 h in simulated intestinal fluid (SIF; pH 7.4). A 1:2:1 (w/w/w) ratio of CTS:OKG:DFNa prepared at room temperature for 3 hours gave the highest % encapsulation efficiency (EE) of 95.6 ± 0.6 and resulted in a minimal release of DFNa (<1% over 2 h) in SGF (pH 1.2) and a significantly improved sustained release in SIF (pH 7.4) with ~6% and 19% release over 8 and 24 h, respectively), some 15- and five-fold lower than that of the two commercial DFNa preparations, Diclosian and Voltaren. This formulation may be used for further study as a long term intestine controlled release drug model (at least 3 days). Molecular Diversity Preservation International 2011-09-23 /pmc/articles/PMC3225940/ /pubmed/22131963 http://dx.doi.org/10.3390/md9091649 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Korkiatithaweechai, Suphat
Umsarika, Pornpusadee
Praphairaksit, Narong
Muangsin, Nongnuj
Controlled Release of Diclofenac from Matrix Polymer of Chitosan and Oxidized Konjac Glucomannan
title Controlled Release of Diclofenac from Matrix Polymer of Chitosan and Oxidized Konjac Glucomannan
title_full Controlled Release of Diclofenac from Matrix Polymer of Chitosan and Oxidized Konjac Glucomannan
title_fullStr Controlled Release of Diclofenac from Matrix Polymer of Chitosan and Oxidized Konjac Glucomannan
title_full_unstemmed Controlled Release of Diclofenac from Matrix Polymer of Chitosan and Oxidized Konjac Glucomannan
title_short Controlled Release of Diclofenac from Matrix Polymer of Chitosan and Oxidized Konjac Glucomannan
title_sort controlled release of diclofenac from matrix polymer of chitosan and oxidized konjac glucomannan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225940/
https://www.ncbi.nlm.nih.gov/pubmed/22131963
http://dx.doi.org/10.3390/md9091649
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