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Challenges in the clinical application of induced pluripotent stem cells

The advent of human induced pluripotent stem cells has been heralded as a major breakthrough in the study of pluripotent stem cells, for these cells have yielded fundamental insights into the reprogrammability of somatic cell fates, but also because of their seemingly great promise in applications,...

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Detalles Bibliográficos
Autor principal: Sipp, Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226303/
https://www.ncbi.nlm.nih.gov/pubmed/20504290
http://dx.doi.org/10.1186/scrt9
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author Sipp, Douglas
author_facet Sipp, Douglas
author_sort Sipp, Douglas
collection PubMed
description The advent of human induced pluripotent stem cells has been heralded as a major breakthrough in the study of pluripotent stem cells, for these cells have yielded fundamental insights into the reprogrammability of somatic cell fates, but also because of their seemingly great promise in applications, including potential uses in cell therapy. Several recent reports in the scientific literature and mass media, however, have challenged this concept for reasons of biological function and business feasibility, presenting an important opportunity to re-examine the prospects for human induced pluripotent stem cells in medicine. In this commentary, I will outline a number of hurdles that will need to be cleared if these cells are to fulfil their clinical promise, and suggest avenues that might facilitate these important endeavours.
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spelling pubmed-32263032011-11-30 Challenges in the clinical application of induced pluripotent stem cells Sipp, Douglas Stem Cell Res Ther Commentary The advent of human induced pluripotent stem cells has been heralded as a major breakthrough in the study of pluripotent stem cells, for these cells have yielded fundamental insights into the reprogrammability of somatic cell fates, but also because of their seemingly great promise in applications, including potential uses in cell therapy. Several recent reports in the scientific literature and mass media, however, have challenged this concept for reasons of biological function and business feasibility, presenting an important opportunity to re-examine the prospects for human induced pluripotent stem cells in medicine. In this commentary, I will outline a number of hurdles that will need to be cleared if these cells are to fulfil their clinical promise, and suggest avenues that might facilitate these important endeavours. BioMed Central 2010-04-12 /pmc/articles/PMC3226303/ /pubmed/20504290 http://dx.doi.org/10.1186/scrt9 Text en Copyright ©2010 BioMed Central Ltd
spellingShingle Commentary
Sipp, Douglas
Challenges in the clinical application of induced pluripotent stem cells
title Challenges in the clinical application of induced pluripotent stem cells
title_full Challenges in the clinical application of induced pluripotent stem cells
title_fullStr Challenges in the clinical application of induced pluripotent stem cells
title_full_unstemmed Challenges in the clinical application of induced pluripotent stem cells
title_short Challenges in the clinical application of induced pluripotent stem cells
title_sort challenges in the clinical application of induced pluripotent stem cells
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226303/
https://www.ncbi.nlm.nih.gov/pubmed/20504290
http://dx.doi.org/10.1186/scrt9
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