Cargando…

β-Catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial–myofibroblast transition

Injury to the adherens junctions (AJs) synergizes with transforming growth factor-β1 (TGFβ) to activate a myogenic program (α-smooth muscle actin [SMA] expression) in the epithelium during epithelial–myofibroblast transition (EMyT). Although this synergy plays a key role in organ fibrosis, the under...

Descripción completa

Detalles Bibliográficos
Autores principales:	Charbonney, Emmanuel, Speight, Pam, Masszi, András, Nakano, Hiroyasu, Kapus, András
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226468/ https://www.ncbi.nlm.nih.gov/pubmed/21965288 http://dx.doi.org/10.1091/mbc.E11-04-0335

Ejemplares similares

Fate-determining mechanisms in epithelial–myofibroblast transition: major inhibitory role for Smad3
por: Masszi, András, et al.
Publicado: (2010)

Differential topical susceptibility to TGFβ in intact and injured regions of the epithelium: key role in myofibroblast transition
por: Speight, Pam, et al.
Publicado: (2013)

Myocardin-related transcription factor and serum response factor regulate cilium turnover by both transcriptional and local mechanisms
por: Speight, Pam, et al.
Publicado: (2021)

How do your contacts (or their absence) shape your fate?
por: Charbonney, Emmanuel, et al.
Publicado: (2013)

The fate of the primary cilium during myofibroblast transition
por: Rozycki, Matthew, et al.
Publicado: (2014)

Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3
por: Speight, Pam, et al.
Publicado: (2016)

Central role of the exchange factor GEF-H1 in TNF-α–induced sequential activation of Rac, ADAM17/TACE, and RhoA in tubular epithelial cells
por: Waheed, Faiza, et al.
Publicado: (2013)

In Search of Novel Targets for Heart Disease: Myocardin and Myocardin-Related Transcriptional Cofactors
por: Mikhailov, Alexander T., et al.
Publicado: (2012)

Dual roles of myocardin-related transcription factors in epithelial–mesenchymal transition via slug induction and actin remodeling
por: Morita, Tsuyoshi, et al.
Publicado: (2007)

Myocardin-Related Transcription Factors-A and -B are Key Regulators of TGF-β1-Induced Fibroblast to Myofibroblast Differentiation
por: Crider, Beverly J., et al.
Publicado: (2011)

Mediated nuclear import and export of TAZ and the underlying molecular requirements
por: Kofler, Michael, et al.
Publicado: (2018)

PD-L1 mediates lung fibroblast to myofibroblast transition through Smad3 and β-catenin signaling pathways
por: Guo, Xia, et al.
Publicado: (2022)

Nuclear translocation of myocardin-related transcription factor-A during transforming growth factor beta–induced epithelial to mesenchymal transition of lens epithelial cells
por: Gupta, Madhuja, et al.
Publicado: (2013)

Myocardin in biology and disease
por: Miano, Joseph M
Publicado: (2015)

Profibrotic epithelial phenotype: a central role for MRTF and TAZ
por: Bialik, Janne Folke, et al.
Publicado: (2019)

Myocardin regulates mitochondrial calcium homeostasis and prevents permeability transition
por: Mughal, Wajihah, et al.
Publicado: (2018)

Kindlin-2 Mediates Mechanical Activation of Cardiac Myofibroblasts
por: Godbout, Elena, et al.
Publicado: (2020)

Correction to: Myocardin regulates mitochondrial calcium homeostasis and prevents permeability transition
por: Mughal, Wajihah, et al.
Publicado: (2019)

Umbilical cord/placenta-derived mesenchymal stem cells inhibit fibrogenic activation in human intestinal myofibroblasts via inhibition of myocardin-related transcription factor A
por: Choi, Yoon Jeong, et al.
Publicado: (2019)

Regulation of the Muscarinic M(3) Receptor by Myocardin-Related Transcription Factors
por: Liu, Li, et al.
Publicado: (2021)

Persistent Hypoxia with Intermittent Aggravation Causes Imbalance in Smad3/Myocardin-Related Transcription Factor Signaling with Consequent Endothelial Senescence and Pulmonary Arterial Remodeling
por: Hu, Jiaxin, et al.
Publicado: (2023)

Smad3 Promotes Cancer‐Associated Fibroblasts Generation via Macrophage–Myofibroblast Transition
por: Tang, Philip Chiu‐Tsun, et al.
Publicado: (2021)

A little (up)SET THEORY: a philosophical and psychological pondering of a scientist on the state of our art
por: Kapus, András
Publicado: (2015)

Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src
por: Tsang, Jennifer LY, et al.
Publicado: (2016)

Erratum: Regulation of the Muscarinic M(3) Receptor by Myocardin-Related Transcription Factors
por: Frontiers Production Office,
Publicado: (2021)

Cell Type Dependent Suppression of Inflammatory Mediators by Myocardin Related Transcription Factors
por: Liu, Li, et al.
Publicado: (2021)

Progerin mislocalizes myocardin-related transcription factor in Hutchinson–Guilford Progeria syndrome
por: von Kleeck, Ryan, et al.
Publicado: (2022)

Activation of Wnt/β‐catenin signalling is required for TGF‐β/Smad2/3 signalling during myofibroblast proliferation
por: Xu, Liang, et al.
Publicado: (2017)

YY1 directly interacts with myocardin to repress the triad myocardin/SRF/CArG box-mediated smooth muscle gene transcription during smooth muscle phenotypic modulation
por: Zheng, Jian-Pu, et al.
Publicado: (2020)

Myocardin-Related Transcription Factors and SRF are required for cytoskeletal dynamics, invasion and experimental metastasis
por: Medjkane, Souhila, et al.
Publicado: (2009)

A myocardin-adjacent lncRNA balances SRF-dependent gene transcription in the heart
por: Anderson, Douglas M., et al.
Publicado: (2021)

Myocardin Family Members Drive Formation of Caveolae
por: Krawczyk, Katarzyna K., et al.
Publicado: (2015)

β-Catenin/Smad3 Interaction Regulates Transforming Growth Factor-β-Induced Epithelial to Mesenchymal Transition in the Lens
por: Taiyab, Aftab, et al.
Publicado: (2019)

Sirtuin 7 Promotes Mesenchymal to Epithelial Transition by β-Catenin Redistribution and Stabilization
por: Kiran, Shashi, et al.
Publicado: (2020)

Nuclear Import and Export of YAP and TAZ
por: Kofler, Michael, et al.
Publicado: (2023)

Myocardin-related transcription factor A cooperates with brahma-related gene 1 to activate P-selectin transcription
por: Song, Mingzi, et al.
Publicado: (2016)

A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis
por: Shiwen, Xu, et al.
Publicado: (2015)

Smad7:β-catenin complex regulates myogenic gene transcription
por: Tripathi, Soma, et al.
Publicado: (2019)

CDCA7 promotes TGF‐β‐induced epithelial–mesenchymal transition via transcriptionally regulating Smad4/Smad7 in ESCC
por: Li, Hongyi, et al.
Publicado: (2022)

Synergistic Activation of Cardiac Genes by Myocardin and Tbx5
por: Wang, Chunbo, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_v1dhbljfk43sms3upsp1nr55da