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Global Methylation in Exposure Biology and Translational Medical Science

Background: Many groups are actively investigating how the epigenetic state relates to environmental exposures and development of disease, including cancer. There are myriad choices for capturing and measuring the epigenetic state of a tissue, ranging from assessing the total methyl-CpG content to a...

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Autores principales: Nelson, Heather H., Marsit, Carmen J., Kelsey, Karl T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226501/
https://www.ncbi.nlm.nih.gov/pubmed/21669556
http://dx.doi.org/10.1289/ehp.1103423
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author Nelson, Heather H.
Marsit, Carmen J.
Kelsey, Karl T.
author_facet Nelson, Heather H.
Marsit, Carmen J.
Kelsey, Karl T.
author_sort Nelson, Heather H.
collection PubMed
description Background: Many groups are actively investigating how the epigenetic state relates to environmental exposures and development of disease, including cancer. There are myriad choices for capturing and measuring the epigenetic state of a tissue, ranging from assessing the total methyl-CpG content to array-based platforms that simultaneously probe hundreds of thousands of CpG loci. There is an emerging literature that uses CpG methylation at repetitive sequences, including LINE-1 (long interspersed nuclear element-1) elements, to capture the epigenomic state. Objectives: We explored the complexity of using CpG methylation at repetitive sequences in epidemiology and translational medical research and suggest needed avenues of research to clarify its meaning and utility. Conclusions: Among the most urgent avenues of research is the need for prospective studies to eliminate the possibilities of reverse causality, and development of new LINE-1 assays that capture both class of LINE-1 element and copy number.
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spelling pubmed-32265012012-01-04 Global Methylation in Exposure Biology and Translational Medical Science Nelson, Heather H. Marsit, Carmen J. Kelsey, Karl T. Environ Health Perspect Commentary Background: Many groups are actively investigating how the epigenetic state relates to environmental exposures and development of disease, including cancer. There are myriad choices for capturing and measuring the epigenetic state of a tissue, ranging from assessing the total methyl-CpG content to array-based platforms that simultaneously probe hundreds of thousands of CpG loci. There is an emerging literature that uses CpG methylation at repetitive sequences, including LINE-1 (long interspersed nuclear element-1) elements, to capture the epigenomic state. Objectives: We explored the complexity of using CpG methylation at repetitive sequences in epidemiology and translational medical research and suggest needed avenues of research to clarify its meaning and utility. Conclusions: Among the most urgent avenues of research is the need for prospective studies to eliminate the possibilities of reverse causality, and development of new LINE-1 assays that capture both class of LINE-1 element and copy number. National Institute of Environmental Health Sciences 2011-06-13 2011-11 /pmc/articles/PMC3226501/ /pubmed/21669556 http://dx.doi.org/10.1289/ehp.1103423 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Commentary
Nelson, Heather H.
Marsit, Carmen J.
Kelsey, Karl T.
Global Methylation in Exposure Biology and Translational Medical Science
title Global Methylation in Exposure Biology and Translational Medical Science
title_full Global Methylation in Exposure Biology and Translational Medical Science
title_fullStr Global Methylation in Exposure Biology and Translational Medical Science
title_full_unstemmed Global Methylation in Exposure Biology and Translational Medical Science
title_short Global Methylation in Exposure Biology and Translational Medical Science
title_sort global methylation in exposure biology and translational medical science
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226501/
https://www.ncbi.nlm.nih.gov/pubmed/21669556
http://dx.doi.org/10.1289/ehp.1103423
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