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Arsenic Exposure and Motor Function among Children in Bangladesh
Background: Several reports indicate that drinking water arsenic (WAs) and manganese (WMn) are associated with children’s intellectual function. Very little is known, however, about possible associations with other neurologic outcomes such as motor function. Methods: We investigated the associations...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Institute of Environmental Health Sciences
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226503/ https://www.ncbi.nlm.nih.gov/pubmed/21742576 http://dx.doi.org/10.1289/ehp.1103548 |
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author | Parvez, Faruque Wasserman, Gail A. Factor-Litvak, Pam Liu, Xinhua Slavkovich, Vesna Siddique, Abu B. Sultana, Rebeka Sultana, Ruksana Islam, Tariqul Levy, Diane Mey, Jacob L. van Geen, Alexander Khan, Khalid Kline, Jennie Ahsan, Habibul Graziano, Joseph H. |
author_facet | Parvez, Faruque Wasserman, Gail A. Factor-Litvak, Pam Liu, Xinhua Slavkovich, Vesna Siddique, Abu B. Sultana, Rebeka Sultana, Ruksana Islam, Tariqul Levy, Diane Mey, Jacob L. van Geen, Alexander Khan, Khalid Kline, Jennie Ahsan, Habibul Graziano, Joseph H. |
author_sort | Parvez, Faruque |
collection | PubMed |
description | Background: Several reports indicate that drinking water arsenic (WAs) and manganese (WMn) are associated with children’s intellectual function. Very little is known, however, about possible associations with other neurologic outcomes such as motor function. Methods: We investigated the associations of WAs and WMn with motor function in 304 children in Bangladesh, 8–11 years of age. We measured As and Mn concentrations in drinking water, blood, urine, and toenails. We assessed motor function with the Bruininks-Oseretsky test, version 2, in four subscales—fine manual control (FMC), manual coordination (MC), body coordination (BC), and strength and agility—which can be summarized with a total motor composite score (TMC). Results: Log-transformed blood As was associated with decreases in TMC [β = –3.63; 95% confidence interval (CI): –6.72, –0.54; p < 0.01], FMC (β = –1.68; 95% CI: –3.19, –0.18; p < 0.05), and BC (β = –1.61; 95% CI: –2.72, –0.51; p < 0.01), with adjustment for sex, school attendance, head circumference, mother’s intelligence, plasma ferritin, and blood Mn, lead, and selenium. Other measures of As exposure (WAs, urinary As, and toenail As) also were inversely associated with motor function scores, particularly TMC and BC. Square-transformed blood selenium was positively associated with TMC (β = 3.54; 95% CI: 1.10, 6.0; p < 0.01), FMC (β = 1.55; 95% CI: 0.40, 2.70; p < 0.005), and MC (β = 1.57; 95% CI: 0.60, 2.75; p < 0.005) in the unadjusted models. Mn exposure was not significantly associated with motor function. Conclusion: Our research demonstrates an adverse association of As exposure and a protective association of Se on motor function in children. |
format | Online Article Text |
id | pubmed-3226503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-32265032012-01-04 Arsenic Exposure and Motor Function among Children in Bangladesh Parvez, Faruque Wasserman, Gail A. Factor-Litvak, Pam Liu, Xinhua Slavkovich, Vesna Siddique, Abu B. Sultana, Rebeka Sultana, Ruksana Islam, Tariqul Levy, Diane Mey, Jacob L. van Geen, Alexander Khan, Khalid Kline, Jennie Ahsan, Habibul Graziano, Joseph H. Environ Health Perspect Research Background: Several reports indicate that drinking water arsenic (WAs) and manganese (WMn) are associated with children’s intellectual function. Very little is known, however, about possible associations with other neurologic outcomes such as motor function. Methods: We investigated the associations of WAs and WMn with motor function in 304 children in Bangladesh, 8–11 years of age. We measured As and Mn concentrations in drinking water, blood, urine, and toenails. We assessed motor function with the Bruininks-Oseretsky test, version 2, in four subscales—fine manual control (FMC), manual coordination (MC), body coordination (BC), and strength and agility—which can be summarized with a total motor composite score (TMC). Results: Log-transformed blood As was associated with decreases in TMC [β = –3.63; 95% confidence interval (CI): –6.72, –0.54; p < 0.01], FMC (β = –1.68; 95% CI: –3.19, –0.18; p < 0.05), and BC (β = –1.61; 95% CI: –2.72, –0.51; p < 0.01), with adjustment for sex, school attendance, head circumference, mother’s intelligence, plasma ferritin, and blood Mn, lead, and selenium. Other measures of As exposure (WAs, urinary As, and toenail As) also were inversely associated with motor function scores, particularly TMC and BC. Square-transformed blood selenium was positively associated with TMC (β = 3.54; 95% CI: 1.10, 6.0; p < 0.01), FMC (β = 1.55; 95% CI: 0.40, 2.70; p < 0.005), and MC (β = 1.57; 95% CI: 0.60, 2.75; p < 0.005) in the unadjusted models. Mn exposure was not significantly associated with motor function. Conclusion: Our research demonstrates an adverse association of As exposure and a protective association of Se on motor function in children. National Institute of Environmental Health Sciences 2011-07-08 2011-11 /pmc/articles/PMC3226503/ /pubmed/21742576 http://dx.doi.org/10.1289/ehp.1103548 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Parvez, Faruque Wasserman, Gail A. Factor-Litvak, Pam Liu, Xinhua Slavkovich, Vesna Siddique, Abu B. Sultana, Rebeka Sultana, Ruksana Islam, Tariqul Levy, Diane Mey, Jacob L. van Geen, Alexander Khan, Khalid Kline, Jennie Ahsan, Habibul Graziano, Joseph H. Arsenic Exposure and Motor Function among Children in Bangladesh |
title | Arsenic Exposure and Motor Function among Children in Bangladesh |
title_full | Arsenic Exposure and Motor Function among Children in Bangladesh |
title_fullStr | Arsenic Exposure and Motor Function among Children in Bangladesh |
title_full_unstemmed | Arsenic Exposure and Motor Function among Children in Bangladesh |
title_short | Arsenic Exposure and Motor Function among Children in Bangladesh |
title_sort | arsenic exposure and motor function among children in bangladesh |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226503/ https://www.ncbi.nlm.nih.gov/pubmed/21742576 http://dx.doi.org/10.1289/ehp.1103548 |
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