A Comparison of the α2/3/5 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain

GABA(A) receptors containing α2/3 subunits are current targets in the battle to develop new pain medications, as they are expressed in the spinal cord where increasing inhibitory drive should result in analgesia. However, this approach is prone to a range of side effects including sedation, cognitiv...

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Detalles Bibliográficos
Autores principales: Nickolls, Sarah, Mace, Hannah, Fish, Rebecca, Edye, Michelle, Gurrell, Rachel, Ivarsson, Magnus, Pitcher, Tom, Tanimoto-Mori, Sachi, Richardson, Denise, Sweatman, Catherine, Nicholson, Janet, Ward, Cameron, Jinks, John, Bell, Christine, Young, Kimberly, Rees, Huw, Moss, Andrew, Kinloch, Ross, McMurray, Gordon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226534/
https://www.ncbi.nlm.nih.gov/pubmed/22162674
http://dx.doi.org/10.1155/2011/608912

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