Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in cystic fibrosis cells

BACKGROUND: Excessive secretion of IL-8 characterizes cystic fibrosis (CF). This has been attributed to excessive activation of epithelial cell I-κB Kinase and/or NFκB. Maximum IL-8 production requires 3 cooperative mechanisms: 1) release of the promoter from repression; 2) activation of transcripti...

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Detalles Bibliográficos
Autores principales: Saadane, Aicha, Eastman, Jean, Berger, Melvin, Bonfield, Tracey L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226551/
https://www.ncbi.nlm.nih.gov/pubmed/21992677
http://dx.doi.org/10.1186/1476-9255-8-26

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