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Increased Expression of PS1 Is Sufficient to Elevate the Level and Activity of γ-Secretase In Vivo
Increase in the generation and deposition of amyloid-β (Aβ) plays a central role in the development of Alzheimer's Disease (AD). Elevation of the activity of γ-secretase, a key enzyme required for the generation for Aβ, can thus be a potential risk factor in AD. However, it is not known whether...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226664/ https://www.ncbi.nlm.nih.gov/pubmed/22140537 http://dx.doi.org/10.1371/journal.pone.0028179 |