Inhibition of Hedgehog Signaling Antagonizes Serous Ovarian Cancer Growth in a Primary Xenograft Model

BACKGROUND: Recent evidence links aberrant activation of Hedgehog (Hh) signaling with the pathogenesis of several cancers including medulloblastoma, basal cell, small cell lung, pancreatic, prostate and ovarian. This investigation was designed to determine if inhibition of this pathway could inhibit...

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Detalles Bibliográficos
Autores principales: McCann, Christopher K., Growdon, Whitfield B., Kulkarni-Datar, Kashmira, Curley, Michael D., Friel, Anne M., Proctor, Jennifer L., Sheikh, Hana, Deyneko, Igor, Ferguson, Jeanne A., Vathipadiekal, Vinod, Birrer, Michael J., Borger, Darrell R., Mohapatra, Gayatry, Zukerberg, Lawrence R., Foster, Rosemary, MacDougall, John R., Rueda, Bo R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226669/
https://www.ncbi.nlm.nih.gov/pubmed/22140510
http://dx.doi.org/10.1371/journal.pone.0028077

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