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Neurotrophic Effect of Citrus 5-Hydroxy-3,6,7,8,3′,4′-Hexamethoxyflavone: Promotion of Neurite Outgrowth via cAMP/PKA/CREB Pathway in PC12 Cells

5-Hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone (5-OH-HxMF), a hydroxylated polymethoxyflavone, is found exclusively in the Citrus genus, particularly in the peels of sweet orange. In this research, we report the first investigation of the neurotrophic effects and mechanism of 5-OH-HxMF in PC12 pheochrom...

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Detalles Bibliográficos
Autores principales:	Lai, Hui-Chi, Wu, Ming-Jiuan, Chen, Pei-Yi, Sheu, Ting-Ting, Chiu, Szu-Ping, Lin, Meng-Han, Ho, Chi-Tang, Yen, Jui-Hung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226691/ https://www.ncbi.nlm.nih.gov/pubmed/22140566 http://dx.doi.org/10.1371/journal.pone.0028280

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