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Thermodynamic coupling between activation and inactivation gating in potassium channels revealed by free energy molecular dynamics simulations
The amount of ionic current flowing through K(+) channels is determined by the interplay between two separate time-dependent processes: activation and inactivation gating. Activation is concerned with the stimulus-dependent opening of the main intracellular gate, whereas inactivation is a spontaneou...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226968/ https://www.ncbi.nlm.nih.gov/pubmed/22124115 http://dx.doi.org/10.1085/jgp.201110670 |