Cargando…

Diverse inflammatory responses in transgenic mouse models of Alzheimer's disease and the effect of immunotherapy on these responses

While the presence of an inflammatory response in AD (Alzheimer's disease) is well known, the data on inflammation are conflicting, suggesting that inflammation either attenuates pathology, exacerbates it or has no effect. Our goal was to more fully characterize the inflammatory response in APP...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wilcock, Donna M, Zhao, Qun, Morgan, Dave, Gordon, Marcia N, Everhart, Angela, Wilson, Joan G, Lee, Jennifer E, Colton, Carol A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Neurochemistry 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227004/ https://www.ncbi.nlm.nih.gov/pubmed/21995345 http://dx.doi.org/10.1042/AN20110018

Ejemplares similares

Lithium Treatment of APPSwDI/NOS2−/− Mice Leads to Reduced Hyperphosphorylated Tau, Increased Amyloid Deposition and Altered Inflammatory Phenotype
por: Sudduth, Tiffany L., et al.
Publicado: (2012)

Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence
por: Wilcock, Donna M, et al.
Publicado: (2011)

mNos2 Deletion and Human NOS2 Replacement in Alzheimer Disease Models
por: Colton, Carol A., et al.
Publicado: (2014)

Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage
por: Wilcock, Donna M, et al.
Publicado: (2004)

Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice
por: Dickey, Chad A, et al.
Publicado: (2005)

Intracranial Injection of AAV Expressing NEP but Not IDE Reduces Amyloid Pathology in APP+PS1 Transgenic Mice
por: Carty, Nikisha, et al.
Publicado: (2013)

The impact of human and mouse differences in NOS2 gene expression on the brain’s redox and immune environment
por: Hoos, Michael D, et al.
Publicado: (2014)

Metabolism-Based Gene Differences in Neurons Expressing Hyperphosphorylated AT8− Positive (AT8+) Tau in Alzheimer’s Disease
por: York, Audra, et al.
Publicado: (2021)

Intracranial administration of deglycosylated C-terminal-specific anti-Aβ antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice
por: Carty, Niki C, et al.
Publicado: (2006)

Ketogenic Diet Improves Motor Performance but Not Cognition in Two Mouse Models of Alzheimer’s Pathology
por: Brownlow, Milene L., et al.
Publicado: (2013)

TRANSGENIC MOUSE MODELS OF ALZHEIMER’S DISEASE
por: Henry-Smith, Charnae A, et al.
Publicado: (2019)

A Changing Perspective on the Role of Neuroinflammation in Alzheimer's Disease
por: Wilcock, Donna M.
Publicado: (2012)

A transgenic mouse model for tumour immunotherapy: induction of an anti-idiotype response to human MUC1
por: Wilkinson, R W, et al.
Publicado: (2000)

Neuroinflammation in the Aging Down Syndrome Brain; Lessons from Alzheimer's Disease
por: Wilcock, Donna M.
Publicado: (2012)

Infectious hypothesis of Alzheimer disease
por: Seaks, Charles E., et al.
Publicado: (2020)

Down’s syndrome, neuroinflammation, and Alzheimer neuropathogenesis
por: Wilcock, Donna M, et al.
Publicado: (2013)

Neuron Loss in Transgenic Mouse Models of Alzheimer's Disease
por: Wirths, Oliver, et al.
Publicado: (2010)

Neonatal Neurodegeneration in Alzheimer’s Disease Transgenic Mouse Model
por: Mazi, Aise Rumeysa, et al.
Publicado: (2018)

Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis
por: Sanchez-Varo, Raquel, et al.
Publicado: (2022)

The Important Interface Between Apolipoprotein E and Neuroinflammation in Alzheimer’s Disease
por: Kloske, Courtney M., et al.
Publicado: (2020)

Recent Alzheimer's disease research highlights
por: Galasko, Douglas, et al.
Publicado: (2012)

Identifying Vulnerable Brain Networks in Mouse Models of Genetic Risk Factors for Late Onset Alzheimer’s Disease
por: Badea, Alexandra, et al.
Publicado: (2019)

Expression of aquaporins in a transgenic mouse model of Alzheimer's disease
por: Chan, Sic L, et al.
Publicado: (2010)

Neuron Loss in Alzheimer’s Disease: Translation in Transgenic Mouse Models
por: Wirths, Oliver, et al.
Publicado: (2020)

IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer’s Disease Transgenic Mouse Model
por: Sohrabi, Mona, et al.
Publicado: (2020)

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain
por: Colton, Carol A.
Publicado: (2009)

Parallels between retinal and brain pathology and response to immunotherapy in old, late‐stage Alzheimer's disease mouse models
por: Doustar, Jonah, et al.
Publicado: (2020)

Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer’s Disease
por: Kasza, Ágnes, et al.
Publicado: (2016)

CVN‐AD Alzheimer's mice show premature reduction in neurovascular coupling in response to spreading depression and anoxia compared to aged controls
por: Turner, Dennis A., et al.
Publicado: (2021)

Welcome to Alzheimer's Research & Therapy
por: Donnelly, Ann, et al.
Publicado: (2009)

Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease
por: Chouliaras, L., et al.
Publicado: (2010)

Gene-Environment Interaction Research and Transgenic Mouse Models of Alzheimer's Disease
por: Chouliaras, L., et al.
Publicado: (2011)

Effects of NK-4 in a Transgenic Mouse Model of Alzheimer's Disease
por: Ohta, Hitomi, et al.
Publicado: (2012)

Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer’s Disease
por: Unger, M. S., et al.
Publicado: (2016)

Peripheral adaptive immunity of the triple transgenic mouse model of Alzheimer’s disease
por: St-Amour, Isabelle, et al.
Publicado: (2019)

Dendritic complexity change in the triple transgenic mouse model of Alzheimer’s disease
por: Zhang, Yu, et al.
Publicado: (2020)

Progressive sleep disturbance in various transgenic mouse models of Alzheimer’s disease
por: Drew, Victor J., et al.
Publicado: (2023)

Connexin diversity in the heart: insights from transgenic mouse models
por: Verheule, Sander, et al.
Publicado: (2013)

Gut microbiota diversity and composition in predicting immunotherapy response and immunotherapy-related colitis in melanoma patients: A systematic review
por: Oey, Oliver, et al.
Publicado: (2022)

CD40 deficiency mitigates Alzheimer's disease pathology in transgenic mouse models
por: Laporte, Vincent, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_8htkfu0j168q189tt0m19bj204