Cargando…

Understanding the Mechanism of Insulin and Insulin-Like Growth Factor (IGF) Receptor Activation by IGF-II

BACKGROUND: Insulin-like growth factor-II (IGF-II) promotes cell proliferation and survival and plays an important role in normal fetal development and placental function. IGF-II binds both the insulin-like growth factor receptor (IGF-1R) and insulin receptor isoform A (IR-A) with high affinity. Int...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alvino, Clair L., Ong, Shee Chee, McNeil, Kerrie A., Delaine, Carlie, Booker, Grant W., Wallace, John C., Forbes, Briony E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227035/ https://www.ncbi.nlm.nih.gov/pubmed/22140443 http://dx.doi.org/10.1371/journal.pone.0027488

Ejemplares similares

How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor
por: Xu, Yibin, et al.
Publicado: (2020)

Determinants of IGF-II influencing stability, receptor binding and activation
por: Blyth, Andrew, et al.
Publicado: (2022)

Minimizing Mitogenic Potency of Insulin Analogues Through Modification of a Disulfide Bond
por: Ong, Shee Chee, et al.
Publicado: (2022)

Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity
por: van Lierop, Bianca, et al.
Publicado: (2017)

Understanding IGF-II Action through Insights into Receptor Binding and Activation
por: Blyth, Andrew J., et al.
Publicado: (2020)

How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor
por: Xu, Yibin, et al.
Publicado: (2022)

IGF-I, IGF-II, and Insulin Stimulate Different Gene Expression Responses through Binding to the IGF-I Receptor
por: Versteyhe, Soetkin, et al.
Publicado: (2013)

Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer
por: Renehan, A G, et al.
Publicado: (2000)

Identification of insulin-like growth factor (IGF)-I and IGF-binding protein in chylous ascites.
por: Lee, D. Y.
Publicado: (1998)

Insulin-like growth factor (IGF)-I and IGF binding proteins axis in diabetes mellitus
por: Kim, Min Sun, et al.
Publicado: (2015)

A prospective study of serum insulin-like growth factor-I (IGF-I), IGF-II, IGF-binding protein-3 and breast cancer risk
por: Allen, N E, et al.
Publicado: (2005)

Serum insulin-like growth factor (IGF)-I and IGF-binding proteins in lung cancer patients.
por: Lee, D. Y., et al.
Publicado: (1999)

Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)
por: Bates, P., et al.
Publicado: (1995)

Total Chemical Synthesis of Palmitoyl-Conjugated Insulin
por: Liu, Mengjie, et al.
Publicado: (2023)

Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions
por: Garrett, Sara M., et al.
Publicado: (2019)

The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila
por: Ikeya, Tomoatsu, et al.
Publicado: (2009)

Insulin-Like Growth Factor (IGF) System in Liver Diseases
por: Adamek, Agnieszka, et al.
Publicado: (2018)

Insulin-like Growth Factor-2 (IGF-2) in Fibrosis
por: Zhu, Yuhan, et al.
Publicado: (2022)

Immunolocalization of insulin-like growth factor-I (IGF-I) and its receptors (IGF-IR) in the equine epididymis
por: YOON, Minjung, et al.
Publicado: (2014)

Insulin‐like Growth Factor (IGF)‐I, IGF‐binding Protein‐3 and Colorectal Adenomas in Japanese Men
por: Teramukai, Satoshi, et al.
Publicado: (2002)

Central insulin‐like growth factor‐1 (IGF‐1) restores whole‐body insulin action in a model of age‐related insulin resistance and IGF‐1 decline
por: Huffman, Derek M., et al.
Publicado: (2015)

Liver mitochondrial dysfunction is reverted by insulin-like growth factor II (IGF-II) in aging rats
por: Garcia-Fernandez, Maria, et al.
Publicado: (2011)

A Fasting Insulin–Raising Allele at IGF1 Locus Is Associated with Circulating Levels of IGF-1 and Insulin Sensitivity
por: Mannino, Gaia Chiara, et al.
Publicado: (2013)

IGF1 and IGF2 specificities to the two insulin receptor isoforms are determined by insulin receptor amino acid 718
por: Andersen, Mie, et al.
Publicado: (2017)

How ligand binds to the type 1 insulin-like growth factor receptor
por: Xu, Yibin, et al.
Publicado: (2018)

Insulin growth factor 1 like receptor (IGF-1R)
por: Iyer, Gopal, et al.
Publicado: (2016)

Free Insulin-like Growth Factor (IGF)-I in Children with PWS
por: Damen, Layla, et al.
Publicado: (2022)

Insulin-Like Growth Factor (IGF) Pathway Targeting in Cancer: Role of the IGF Axis and Opportunities for Future Combination Studies
por: Simpson, Aaron, et al.
Publicado: (2017)

Disrupting Insulin and IGF Receptor Function in Cancer
por: Cao, Jingran, et al.
Publicado: (2021)

Effects of human insulin and insulin aspart preparations on levels of IGF-I, IGFBPs and IGF bioactivity in patients with type 1 diabetes
por: Ma, Zhulin, et al.
Publicado: (2014)

Insulin-Like Growth Factor (IGF)-I and Insulin in Normal and Growth-Restricted Mother/Infant Pairs
por: Malamitsi-Puchner, Ariadne, et al.
Publicado: (2007)

Production of immunoreactive insulin-like growth factor-I (IGF-I) and IGF-I binding proteins by human lung tumours.
por: Reeve, J. G., et al.
Publicado: (1990)

The putative role of insulin-like growth factor (IGF)-binding protein 5 independent of IGF in the maintenance of pulpal homeostasis in mice
por: Saito, Kotaro, et al.
Publicado: (2019)

Specific insulin/IGF1 hybrid receptor activation assay reveals IGF1 as a more potent ligand than insulin
por: Slaaby, Rita
Publicado: (2015)

Associations among IGF-1, IGF2, IGF-1R, IGF-2R, IGFBP-3, insulin genetic polymorphisms and central precocious puberty in girls
por: Chang, Hua-Pin, et al.
Publicado: (2018)

Human conditions of insulin-like growth factor-I (IGF-I) deficiency
por: Puche, Juan E, et al.
Publicado: (2012)

Characterization of insulin-like-growth factor II (IGF II) mRNA positive hepatic altered foci and IGF II expression in hepatocellular carcinoma during diethylnitrosamine-induced hepatocarcinogenesis in rats
por: Mukherjee, Biswajit, et al.
Publicado: (2005)

Inhibition of insulin-like growth factor II (IGF-II)-dependent cell growth by multidentate pentamannosyl 6-phosphate-based ligands targeting the mannose 6-phosphate/IGF-II receptor
por: Zavorka, Megan E., et al.
Publicado: (2016)

Identification, Synthesis, Conformation and Activity of an Insulin-like Peptide from a Sea Anemone
por: Mitchell, Michela L., et al.
Publicado: (2021)

Sensitization and translocation of TRPV1 by insulin and IGF-I
por: Van Buren, Jeremy J, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_5vlsmtro329u9k68lqb92u26uf