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Two-stage procedures for selecting the best diagnostic biomarkers

Considered in the paper is the problem of selecting a diagnostic biomarker that has the highest classification rate among several candidate markers with dichotomous outcomes. The probability of correct selection depends on a number of nuisance parameters from the joint distribution of the biomarkers...

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Detalles Bibliográficos
Autores principales: Liu, Aiyi, Wu, Chengqing, Yu, Kai F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227145/
https://www.ncbi.nlm.nih.gov/pubmed/18407902
http://dx.doi.org/10.1098/rsta.2008.0032
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author Liu, Aiyi
Wu, Chengqing
Yu, Kai F.
author_facet Liu, Aiyi
Wu, Chengqing
Yu, Kai F.
author_sort Liu, Aiyi
collection PubMed
description Considered in the paper is the problem of selecting a diagnostic biomarker that has the highest classification rate among several candidate markers with dichotomous outcomes. The probability of correct selection depends on a number of nuisance parameters from the joint distribution of the biomarkers and thus can be substantially affected if these nuisance parameters are misspecified. A two-stage procedure is proposed to compute the needed sample size that achieves the desired level of correct selection, as so confirmed by simulation results.
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spelling pubmed-32271452011-11-30 Two-stage procedures for selecting the best diagnostic biomarkers Liu, Aiyi Wu, Chengqing Yu, Kai F. Philos Trans A Math Phys Eng Sci Research Article Considered in the paper is the problem of selecting a diagnostic biomarker that has the highest classification rate among several candidate markers with dichotomous outcomes. The probability of correct selection depends on a number of nuisance parameters from the joint distribution of the biomarkers and thus can be substantially affected if these nuisance parameters are misspecified. A two-stage procedure is proposed to compute the needed sample size that achieves the desired level of correct selection, as so confirmed by simulation results. The Royal Society 2008-04-11 2008-07-13 /pmc/articles/PMC3227145/ /pubmed/18407902 http://dx.doi.org/10.1098/rsta.2008.0032 Text en Copyright © 2008 The Royal Society http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liu, Aiyi
Wu, Chengqing
Yu, Kai F.
Two-stage procedures for selecting the best diagnostic biomarkers
title Two-stage procedures for selecting the best diagnostic biomarkers
title_full Two-stage procedures for selecting the best diagnostic biomarkers
title_fullStr Two-stage procedures for selecting the best diagnostic biomarkers
title_full_unstemmed Two-stage procedures for selecting the best diagnostic biomarkers
title_short Two-stage procedures for selecting the best diagnostic biomarkers
title_sort two-stage procedures for selecting the best diagnostic biomarkers
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227145/
https://www.ncbi.nlm.nih.gov/pubmed/18407902
http://dx.doi.org/10.1098/rsta.2008.0032
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