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Role of mast cells in pathogenesis of oral lichen planus
Recent attention has been directed toward the role of mast cells in the pathogenesis of oral lichen planus. Mast cells are responsible for trafficking inflammatory cells into the connective tissue that in turn helps in progression and maintenance of chronicity of oral lichen planus (OLP). OLP is a T...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227251/ https://www.ncbi.nlm.nih.gov/pubmed/22144827 http://dx.doi.org/10.4103/0973-029X.86674 |
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author | Sharma, Rachna Sircar, Keya Singh, Sanjeet Rastogi, Varun |
author_facet | Sharma, Rachna Sircar, Keya Singh, Sanjeet Rastogi, Varun |
author_sort | Sharma, Rachna |
collection | PubMed |
description | Recent attention has been directed toward the role of mast cells in the pathogenesis of oral lichen planus. Mast cells are responsible for trafficking inflammatory cells into the connective tissue that in turn helps in progression and maintenance of chronicity of oral lichen planus (OLP). OLP is a T-cell-mediated chronic inflammatory oral mucosal disease of unknown etiology, and lesions contain few B-cells or plasma cells and minimal deposits of immunoglobulin or complement. Hence, OLP is ideally positioned for the study of human T-cell-mediated inflammation and autoimmunity. This study was done to evaluate the mast cell count using toluidine blue stain in OLP and compares it with oral lichenoid reaction (OLR), and to propose the possible role of mast cells in the pathogenesis of OLP and OLR. Ten cases each of OLP and OLR and five cases of normal buccal mucosa were taken from the archives of Department of Oral Pathology. The samples were stained with toluidine blue using standard toluidine blue method by Wolman 1971. An increase in mast cell count was observed in OLP and OLR in comparison to normal oral mucosa. However, no significant differences in mast cell count were noted between OLP and OLR. |
format | Online Article Text |
id | pubmed-3227251 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-32272512011-12-05 Role of mast cells in pathogenesis of oral lichen planus Sharma, Rachna Sircar, Keya Singh, Sanjeet Rastogi, Varun J Oral Maxillofac Pathol Original Article Recent attention has been directed toward the role of mast cells in the pathogenesis of oral lichen planus. Mast cells are responsible for trafficking inflammatory cells into the connective tissue that in turn helps in progression and maintenance of chronicity of oral lichen planus (OLP). OLP is a T-cell-mediated chronic inflammatory oral mucosal disease of unknown etiology, and lesions contain few B-cells or plasma cells and minimal deposits of immunoglobulin or complement. Hence, OLP is ideally positioned for the study of human T-cell-mediated inflammation and autoimmunity. This study was done to evaluate the mast cell count using toluidine blue stain in OLP and compares it with oral lichenoid reaction (OLR), and to propose the possible role of mast cells in the pathogenesis of OLP and OLR. Ten cases each of OLP and OLR and five cases of normal buccal mucosa were taken from the archives of Department of Oral Pathology. The samples were stained with toluidine blue using standard toluidine blue method by Wolman 1971. An increase in mast cell count was observed in OLP and OLR in comparison to normal oral mucosa. However, no significant differences in mast cell count were noted between OLP and OLR. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3227251/ /pubmed/22144827 http://dx.doi.org/10.4103/0973-029X.86674 Text en Copyright: © Journal of Oral and Maxillofacial Pathology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Sharma, Rachna Sircar, Keya Singh, Sanjeet Rastogi, Varun Role of mast cells in pathogenesis of oral lichen planus |
title | Role of mast cells in pathogenesis of oral lichen planus |
title_full | Role of mast cells in pathogenesis of oral lichen planus |
title_fullStr | Role of mast cells in pathogenesis of oral lichen planus |
title_full_unstemmed | Role of mast cells in pathogenesis of oral lichen planus |
title_short | Role of mast cells in pathogenesis of oral lichen planus |
title_sort | role of mast cells in pathogenesis of oral lichen planus |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227251/ https://www.ncbi.nlm.nih.gov/pubmed/22144827 http://dx.doi.org/10.4103/0973-029X.86674 |
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