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Immunohistochemical expression of cyclin D1 in ameloblastomas and adenomatoid odontogenic tumors

BACKGROUND: Cyclin D1, a member of G1 cyclins, controls the cell-cycle transit from the G1 to S phase. The deregulation and overexpression of cyclin D1 has been revealed in many tumors of diverse histogenesis. Ameloblastoma is the most frequently encountered odontogenic tumor known for its local inv...

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Autores principales: Kumar, Harish, Vandana, R, Kumar, GS
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227254/
https://www.ncbi.nlm.nih.gov/pubmed/22144830
http://dx.doi.org/10.4103/0973-029X.86685
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author Kumar, Harish
Vandana, R
Kumar, GS
author_facet Kumar, Harish
Vandana, R
Kumar, GS
author_sort Kumar, Harish
collection PubMed
description BACKGROUND: Cyclin D1, a member of G1 cyclins, controls the cell-cycle transit from the G1 to S phase. The deregulation and overexpression of cyclin D1 has been revealed in many tumors of diverse histogenesis. Ameloblastoma is the most frequently encountered odontogenic tumor known for its local invasiveness and a high tendency to recur. The adenomatoid odontogenic tumor is a benign, nonaggressive tumor with a limited growth and no tendency to recur. AIM: The aim was to investigate whether the immunohistochemical expression of cyclin D1 as a proliferation marker in ameloblastoma and adenomatoid odontogenic tumor correlates with the known clinical behavior of these two benign neoplasms. MATERIALS AND METHODS: Ameloblastoma cases consisted of follicular, plexiform, and unicystic subtypes. The positive staining was assessed based on intensity of staining, localization of staining, and in different cell types in both the tumors. Two cases of follicular ameloblastoma and one case of plexiform ameloblastoma showed intense staining, but the predominant staining intensity was overall mild in both ameloblastoma and adenomatoid odontogenic tumors. The immunoreactivity was found both in nucleus and cytoplasm in ameloblastoma and only nuclear in adenomatoid odontogenic tumors. The peripheral columnar and central stellate reticulum-like cells of ameloblastoma showed immunoreactivity with squamous and granular cells being negative. In adenomatoid odontogenic tumors, the whorls showed predominant localization of staining. Statistical comparison with a Mann–Whitney U-test showed no significant difference in staining intensities between different histologic subtypes of ameloblastomas and also between ameloblastoma and adenomatoid odontogenic tumors (P>0.005). CONCLUSION: The marked expression of cyclin D1 in these tumors suggested its participation in proliferation of both the tumors and its expression patterns were irrespective of their known biologic behavior.
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spelling pubmed-32272542011-12-05 Immunohistochemical expression of cyclin D1 in ameloblastomas and adenomatoid odontogenic tumors Kumar, Harish Vandana, R Kumar, GS J Oral Maxillofac Pathol Original Article BACKGROUND: Cyclin D1, a member of G1 cyclins, controls the cell-cycle transit from the G1 to S phase. The deregulation and overexpression of cyclin D1 has been revealed in many tumors of diverse histogenesis. Ameloblastoma is the most frequently encountered odontogenic tumor known for its local invasiveness and a high tendency to recur. The adenomatoid odontogenic tumor is a benign, nonaggressive tumor with a limited growth and no tendency to recur. AIM: The aim was to investigate whether the immunohistochemical expression of cyclin D1 as a proliferation marker in ameloblastoma and adenomatoid odontogenic tumor correlates with the known clinical behavior of these two benign neoplasms. MATERIALS AND METHODS: Ameloblastoma cases consisted of follicular, plexiform, and unicystic subtypes. The positive staining was assessed based on intensity of staining, localization of staining, and in different cell types in both the tumors. Two cases of follicular ameloblastoma and one case of plexiform ameloblastoma showed intense staining, but the predominant staining intensity was overall mild in both ameloblastoma and adenomatoid odontogenic tumors. The immunoreactivity was found both in nucleus and cytoplasm in ameloblastoma and only nuclear in adenomatoid odontogenic tumors. The peripheral columnar and central stellate reticulum-like cells of ameloblastoma showed immunoreactivity with squamous and granular cells being negative. In adenomatoid odontogenic tumors, the whorls showed predominant localization of staining. Statistical comparison with a Mann–Whitney U-test showed no significant difference in staining intensities between different histologic subtypes of ameloblastomas and also between ameloblastoma and adenomatoid odontogenic tumors (P>0.005). CONCLUSION: The marked expression of cyclin D1 in these tumors suggested its participation in proliferation of both the tumors and its expression patterns were irrespective of their known biologic behavior. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3227254/ /pubmed/22144830 http://dx.doi.org/10.4103/0973-029X.86685 Text en Copyright: © Journal of Oral and Maxillofacial Pathology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kumar, Harish
Vandana, R
Kumar, GS
Immunohistochemical expression of cyclin D1 in ameloblastomas and adenomatoid odontogenic tumors
title Immunohistochemical expression of cyclin D1 in ameloblastomas and adenomatoid odontogenic tumors
title_full Immunohistochemical expression of cyclin D1 in ameloblastomas and adenomatoid odontogenic tumors
title_fullStr Immunohistochemical expression of cyclin D1 in ameloblastomas and adenomatoid odontogenic tumors
title_full_unstemmed Immunohistochemical expression of cyclin D1 in ameloblastomas and adenomatoid odontogenic tumors
title_short Immunohistochemical expression of cyclin D1 in ameloblastomas and adenomatoid odontogenic tumors
title_sort immunohistochemical expression of cyclin d1 in ameloblastomas and adenomatoid odontogenic tumors
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227254/
https://www.ncbi.nlm.nih.gov/pubmed/22144830
http://dx.doi.org/10.4103/0973-029X.86685
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