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Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis

Not only is nephritis a common complaint in systemic lupus erythematosus, but it is also the most life-threatening complication of the disease. Anti-double-stranded DNA antibodies (Abs), which are found in up to 80% of these patients, might be nephritogenic per se. That is, they may cross-react with...

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Autores principales: Seret, Guillaume, Le Meur, Yannick, Renaudineau, Yves, Youinou, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227425/
https://www.ncbi.nlm.nih.gov/pubmed/22162716
http://dx.doi.org/10.1155/2012/579670
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author Seret, Guillaume
Le Meur, Yannick
Renaudineau, Yves
Youinou, Pierre
author_facet Seret, Guillaume
Le Meur, Yannick
Renaudineau, Yves
Youinou, Pierre
author_sort Seret, Guillaume
collection PubMed
description Not only is nephritis a common complaint in systemic lupus erythematosus, but it is also the most life-threatening complication of the disease. Anti-double-stranded DNA antibodies (Abs), which are found in up to 80% of these patients, might be nephritogenic per se. That is, they may cross-react with mesangial cell (MC) surface proteins, such as alpha-actinin and annexin A2, they may cross-react with mesangial matrix protein such as laminine and fibronectin, or they may recognize chromatin material previously deposited in the glomeruli. The consequence of the binding of anti-MC Abs may be their internalization, which results in activation and proliferation of these MCs. In turn, these activated MCs are suspected of promoting immune complex formation by sequestering and thereby protecting chromatin from degradation. The present paper will explain the mechanisms through which such autoAbs may initiate nephritis.
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spelling pubmed-32274252011-12-08 Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis Seret, Guillaume Le Meur, Yannick Renaudineau, Yves Youinou, Pierre Clin Dev Immunol Review Article Not only is nephritis a common complaint in systemic lupus erythematosus, but it is also the most life-threatening complication of the disease. Anti-double-stranded DNA antibodies (Abs), which are found in up to 80% of these patients, might be nephritogenic per se. That is, they may cross-react with mesangial cell (MC) surface proteins, such as alpha-actinin and annexin A2, they may cross-react with mesangial matrix protein such as laminine and fibronectin, or they may recognize chromatin material previously deposited in the glomeruli. The consequence of the binding of anti-MC Abs may be their internalization, which results in activation and proliferation of these MCs. In turn, these activated MCs are suspected of promoting immune complex formation by sequestering and thereby protecting chromatin from degradation. The present paper will explain the mechanisms through which such autoAbs may initiate nephritis. Hindawi Publishing Corporation 2012 2011-11-28 /pmc/articles/PMC3227425/ /pubmed/22162716 http://dx.doi.org/10.1155/2012/579670 Text en Copyright © 2012 Guillaume Seret et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Seret, Guillaume
Le Meur, Yannick
Renaudineau, Yves
Youinou, Pierre
Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis
title Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis
title_full Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis
title_fullStr Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis
title_full_unstemmed Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis
title_short Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis
title_sort mesangial cell-specific antibodies are central to the pathogenesis of lupus nephritis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227425/
https://www.ncbi.nlm.nih.gov/pubmed/22162716
http://dx.doi.org/10.1155/2012/579670
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