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The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome

Background. Extensive evidence, arising from models of endothelial nitric oxide synthase gene (NOS3)-knockout mice supports the role of endothelial malfunction in the pathogenesis of the metabolic syndrome (MS). Aims. The aim of this study was to evaluate the role of −786T/C polymorphism in the etio...

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Autores principales: Misiak, Blazej, Krolik, Marta, Kukowka, Anna, Lewera, Anna, Leszczynski, Przemyslaw, Stankiewicz-Olczyk, Joanna, Slezak, Ryszard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227465/
https://www.ncbi.nlm.nih.gov/pubmed/22164159
http://dx.doi.org/10.1155/2011/458750
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author Misiak, Blazej
Krolik, Marta
Kukowka, Anna
Lewera, Anna
Leszczynski, Przemyslaw
Stankiewicz-Olczyk, Joanna
Slezak, Ryszard
author_facet Misiak, Blazej
Krolik, Marta
Kukowka, Anna
Lewera, Anna
Leszczynski, Przemyslaw
Stankiewicz-Olczyk, Joanna
Slezak, Ryszard
author_sort Misiak, Blazej
collection PubMed
description Background. Extensive evidence, arising from models of endothelial nitric oxide synthase gene (NOS3)-knockout mice supports the role of endothelial malfunction in the pathogenesis of the metabolic syndrome (MS). Aims. The aim of this study was to evaluate the role of −786T/C polymorphism in the etiology of MS and assess previously reported interaction with cigarette smoking. Methods. Based on International Diabetes Federation 2005 criteria, we recruited randomly 152 subjects with MS and 75 subjects without MS. Results. Allelic and genotype frequencies did not differ significantly between both groups. Total cholesterol level (CHOLT) and intima-media thickness of carotid arteries were significantly higher in −786CC homozygotes, in comparison with −786TC and −786TT patients. Regarding current smoking status, −786C allele was associated with higher CHOLT than −786T allele. Conclusion. Our study indicates the putative role of −786T/C polymorphism in the development of hypercholesterolemia, in patients with MS, which might be enhanced by cigarette smoking.
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spelling pubmed-32274652011-12-07 The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome Misiak, Blazej Krolik, Marta Kukowka, Anna Lewera, Anna Leszczynski, Przemyslaw Stankiewicz-Olczyk, Joanna Slezak, Ryszard Int J Endocrinol Research Article Background. Extensive evidence, arising from models of endothelial nitric oxide synthase gene (NOS3)-knockout mice supports the role of endothelial malfunction in the pathogenesis of the metabolic syndrome (MS). Aims. The aim of this study was to evaluate the role of −786T/C polymorphism in the etiology of MS and assess previously reported interaction with cigarette smoking. Methods. Based on International Diabetes Federation 2005 criteria, we recruited randomly 152 subjects with MS and 75 subjects without MS. Results. Allelic and genotype frequencies did not differ significantly between both groups. Total cholesterol level (CHOLT) and intima-media thickness of carotid arteries were significantly higher in −786CC homozygotes, in comparison with −786TC and −786TT patients. Regarding current smoking status, −786C allele was associated with higher CHOLT than −786T allele. Conclusion. Our study indicates the putative role of −786T/C polymorphism in the development of hypercholesterolemia, in patients with MS, which might be enhanced by cigarette smoking. Hindawi Publishing Corporation 2011 2011-11-24 /pmc/articles/PMC3227465/ /pubmed/22164159 http://dx.doi.org/10.1155/2011/458750 Text en Copyright © 2011 Blazej Misiak et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Misiak, Blazej
Krolik, Marta
Kukowka, Anna
Lewera, Anna
Leszczynski, Przemyslaw
Stankiewicz-Olczyk, Joanna
Slezak, Ryszard
The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome
title The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome
title_full The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome
title_fullStr The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome
title_full_unstemmed The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome
title_short The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome
title_sort role of −786t/c polymorphism in the endothelial nitric oxide synthase gene in males with clinical and biochemical features of the metabolic syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227465/
https://www.ncbi.nlm.nih.gov/pubmed/22164159
http://dx.doi.org/10.1155/2011/458750
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