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Disturbed Copper Bioavailability in Alzheimer's Disease
Recent data from in vitro, animal, and human studies have shed new light on the positive roles of copper in many aspects of AD. Copper promotes the non-amyloidogenic processing of APP and thereby lowers the Aβ production in cell culture systems, and it increases lifetime and decreases soluble amyloi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227474/ https://www.ncbi.nlm.nih.gov/pubmed/22145082 http://dx.doi.org/10.4061/2011/345614 |
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author | Kaden, Daniela Bush, Ashley I. Danzeisen, Ruth Bayer, Thomas A. Multhaup, Gerd |
author_facet | Kaden, Daniela Bush, Ashley I. Danzeisen, Ruth Bayer, Thomas A. Multhaup, Gerd |
author_sort | Kaden, Daniela |
collection | PubMed |
description | Recent data from in vitro, animal, and human studies have shed new light on the positive roles of copper in many aspects of AD. Copper promotes the non-amyloidogenic processing of APP and thereby lowers the Aβ production in cell culture systems, and it increases lifetime and decreases soluble amyloid production in APP transgenic mice. In a clinical trial with Alzheimer patients, the decline of Aβ levels in CSF, which is a diagnostic marker, is diminished in the verum group (8 mg copper/day), indicating a beneficial effect of the copper treatment. These observations are in line with the benefit of treatment with compounds aimed at normalizing metal levels in the brain, such as PBT2. The data reviewed here demonstrate that there is an apparent disturbance in metal homeostasis in AD. More research is urgently needed to understand how this disturbance can be addressed therapeutically. |
format | Online Article Text |
id | pubmed-3227474 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-32274742011-12-05 Disturbed Copper Bioavailability in Alzheimer's Disease Kaden, Daniela Bush, Ashley I. Danzeisen, Ruth Bayer, Thomas A. Multhaup, Gerd Int J Alzheimers Dis Review Article Recent data from in vitro, animal, and human studies have shed new light on the positive roles of copper in many aspects of AD. Copper promotes the non-amyloidogenic processing of APP and thereby lowers the Aβ production in cell culture systems, and it increases lifetime and decreases soluble amyloid production in APP transgenic mice. In a clinical trial with Alzheimer patients, the decline of Aβ levels in CSF, which is a diagnostic marker, is diminished in the verum group (8 mg copper/day), indicating a beneficial effect of the copper treatment. These observations are in line with the benefit of treatment with compounds aimed at normalizing metal levels in the brain, such as PBT2. The data reviewed here demonstrate that there is an apparent disturbance in metal homeostasis in AD. More research is urgently needed to understand how this disturbance can be addressed therapeutically. SAGE-Hindawi Access to Research 2011 2011-11-15 /pmc/articles/PMC3227474/ /pubmed/22145082 http://dx.doi.org/10.4061/2011/345614 Text en Copyright © 2011 Daniela Kaden et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Kaden, Daniela Bush, Ashley I. Danzeisen, Ruth Bayer, Thomas A. Multhaup, Gerd Disturbed Copper Bioavailability in Alzheimer's Disease |
title | Disturbed Copper Bioavailability in Alzheimer's Disease |
title_full | Disturbed Copper Bioavailability in Alzheimer's Disease |
title_fullStr | Disturbed Copper Bioavailability in Alzheimer's Disease |
title_full_unstemmed | Disturbed Copper Bioavailability in Alzheimer's Disease |
title_short | Disturbed Copper Bioavailability in Alzheimer's Disease |
title_sort | disturbed copper bioavailability in alzheimer's disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227474/ https://www.ncbi.nlm.nih.gov/pubmed/22145082 http://dx.doi.org/10.4061/2011/345614 |
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