Liver Injury Induced by High-Dose Methylprednisolone Therapy: A Case Report and Brief Review of the Literature

Corticosteroids are used widely to treat many types of disease. In general, these drugs are considered safe for the liver; however, recent reports have demonstrated that high-dose methylprednisolone (MT) may cause severe liver injury. Here, we report a case of a 24-year-old female who was given puls...

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Autores principales: Gutkowski, Krzysztof, Chwist, Alina, Hartleb, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227489/
https://www.ncbi.nlm.nih.gov/pubmed/22140391
http://dx.doi.org/10.5812/kowsar.1735143X.713
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author Gutkowski, Krzysztof
Chwist, Alina
Hartleb, Marek
author_facet Gutkowski, Krzysztof
Chwist, Alina
Hartleb, Marek
author_sort Gutkowski, Krzysztof
collection PubMed
description Corticosteroids are used widely to treat many types of disease. In general, these drugs are considered safe for the liver; however, recent reports have demonstrated that high-dose methylprednisolone (MT) may cause severe liver injury. Here, we report a case of a 24-year-old female who was given pulsed MT therapy for multiple sclerosis. MT induced icteric hepatitis and impaired liver synthetic function. Hepatotoxicity developed several weeks after drug exposure, and the causal association with MT was confirmed by unintentional rechallenge test. A brief review of the literature on corticosteroid-induced hepatotoxicity is presented.
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spelling pubmed-32274892011-12-02 Liver Injury Induced by High-Dose Methylprednisolone Therapy: A Case Report and Brief Review of the Literature Gutkowski, Krzysztof Chwist, Alina Hartleb, Marek Hepat Mon Case Report Corticosteroids are used widely to treat many types of disease. In general, these drugs are considered safe for the liver; however, recent reports have demonstrated that high-dose methylprednisolone (MT) may cause severe liver injury. Here, we report a case of a 24-year-old female who was given pulsed MT therapy for multiple sclerosis. MT induced icteric hepatitis and impaired liver synthetic function. Hepatotoxicity developed several weeks after drug exposure, and the causal association with MT was confirmed by unintentional rechallenge test. A brief review of the literature on corticosteroid-induced hepatotoxicity is presented. Kowsar 2011-08-01 2011-08-01 /pmc/articles/PMC3227489/ /pubmed/22140391 http://dx.doi.org/10.5812/kowsar.1735143X.713 Text en Copyright © 2011, Kowsar M.P. Co. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Gutkowski, Krzysztof
Chwist, Alina
Hartleb, Marek
Liver Injury Induced by High-Dose Methylprednisolone Therapy: A Case Report and Brief Review of the Literature
title Liver Injury Induced by High-Dose Methylprednisolone Therapy: A Case Report and Brief Review of the Literature
title_full Liver Injury Induced by High-Dose Methylprednisolone Therapy: A Case Report and Brief Review of the Literature
title_fullStr Liver Injury Induced by High-Dose Methylprednisolone Therapy: A Case Report and Brief Review of the Literature
title_full_unstemmed Liver Injury Induced by High-Dose Methylprednisolone Therapy: A Case Report and Brief Review of the Literature
title_short Liver Injury Induced by High-Dose Methylprednisolone Therapy: A Case Report and Brief Review of the Literature
title_sort liver injury induced by high-dose methylprednisolone therapy: a case report and brief review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227489/
https://www.ncbi.nlm.nih.gov/pubmed/22140391
http://dx.doi.org/10.5812/kowsar.1735143X.713
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AT chwistalina liverinjuryinducedbyhighdosemethylprednisolonetherapyacasereportandbriefreviewoftheliterature
AT hartlebmarek liverinjuryinducedbyhighdosemethylprednisolonetherapyacasereportandbriefreviewoftheliterature

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