Cargando…
Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure
Stress-activated gene × environment interactions may contribute to individual variability in blood pressure reductions from behavioral interventions. We investigated effects of endothelin-1 (ET-1) LYS198ASN SNP and discriminatory stress exposure upon impact of 12-week behavioral interventions upon a...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227499/ https://www.ncbi.nlm.nih.gov/pubmed/22164329 http://dx.doi.org/10.1155/2012/510291 |
_version_ | 1782217750867869696 |
---|---|
author | Gregoski, Mathew J. Barnes, Vernon A. Tingen, Martha S. Dong, Yanbin Zhu, Haidong Treiber, Frank A. |
author_facet | Gregoski, Mathew J. Barnes, Vernon A. Tingen, Martha S. Dong, Yanbin Zhu, Haidong Treiber, Frank A. |
author_sort | Gregoski, Mathew J. |
collection | PubMed |
description | Stress-activated gene × environment interactions may contribute to individual variability in blood pressure reductions from behavioral interventions. We investigated effects of endothelin-1 (ET-1) LYS198ASN SNP and discriminatory stress exposure upon impact of 12-week behavioral interventions upon ambulatory BP (ABP) among 162 prehypertensive African American adolescents. Following genotyping, completion of questionnaire battery, and 24-hour ABP monitoring, participants were randomized to health education control (HEC), life skills training (LST), or breathing awareness meditation (BAM). Postintervention ABP was obtained. Significant three-way interactions on ABP changes indicated that among ET-1 SNP carriers, the only group to show reductions was BAM from low chronic stress environments. Among ET-1 SNP noncarriers, under low chronic stress exposure, all approaches worked, especially BAM. Among high stress exposure noncarriers, only BAM resulted in reductions. If these preliminary findings are replicated via ancillary analyses of archival databases and then via efficacy trials, selection of behavioral prescriptions for prehypertensives will be edging closer to being guided by individual's underlying genetic and environmental factors incorporating the healthcare model of personalized preventive medicine. |
format | Online Article Text |
id | pubmed-3227499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32274992011-12-07 Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure Gregoski, Mathew J. Barnes, Vernon A. Tingen, Martha S. Dong, Yanbin Zhu, Haidong Treiber, Frank A. Int J Hypertens Research Article Stress-activated gene × environment interactions may contribute to individual variability in blood pressure reductions from behavioral interventions. We investigated effects of endothelin-1 (ET-1) LYS198ASN SNP and discriminatory stress exposure upon impact of 12-week behavioral interventions upon ambulatory BP (ABP) among 162 prehypertensive African American adolescents. Following genotyping, completion of questionnaire battery, and 24-hour ABP monitoring, participants were randomized to health education control (HEC), life skills training (LST), or breathing awareness meditation (BAM). Postintervention ABP was obtained. Significant three-way interactions on ABP changes indicated that among ET-1 SNP carriers, the only group to show reductions was BAM from low chronic stress environments. Among ET-1 SNP noncarriers, under low chronic stress exposure, all approaches worked, especially BAM. Among high stress exposure noncarriers, only BAM resulted in reductions. If these preliminary findings are replicated via ancillary analyses of archival databases and then via efficacy trials, selection of behavioral prescriptions for prehypertensives will be edging closer to being guided by individual's underlying genetic and environmental factors incorporating the healthcare model of personalized preventive medicine. Hindawi Publishing Corporation 2012 2011-11-24 /pmc/articles/PMC3227499/ /pubmed/22164329 http://dx.doi.org/10.1155/2012/510291 Text en Copyright © 2012 Mathew J. Gregoski et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Gregoski, Mathew J. Barnes, Vernon A. Tingen, Martha S. Dong, Yanbin Zhu, Haidong Treiber, Frank A. Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure |
title | Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure |
title_full | Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure |
title_fullStr | Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure |
title_full_unstemmed | Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure |
title_short | Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure |
title_sort | differential impact of stress reduction programs upon ambulatory blood pressure among african american adolescents: influences of endothelin-1 gene and chronic stress exposure |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227499/ https://www.ncbi.nlm.nih.gov/pubmed/22164329 http://dx.doi.org/10.1155/2012/510291 |
work_keys_str_mv | AT gregoskimathewj differentialimpactofstressreductionprogramsuponambulatorybloodpressureamongafricanamericanadolescentsinfluencesofendothelin1geneandchronicstressexposure AT barnesvernona differentialimpactofstressreductionprogramsuponambulatorybloodpressureamongafricanamericanadolescentsinfluencesofendothelin1geneandchronicstressexposure AT tingenmarthas differentialimpactofstressreductionprogramsuponambulatorybloodpressureamongafricanamericanadolescentsinfluencesofendothelin1geneandchronicstressexposure AT dongyanbin differentialimpactofstressreductionprogramsuponambulatorybloodpressureamongafricanamericanadolescentsinfluencesofendothelin1geneandchronicstressexposure AT zhuhaidong differentialimpactofstressreductionprogramsuponambulatorybloodpressureamongafricanamericanadolescentsinfluencesofendothelin1geneandchronicstressexposure AT treiberfranka differentialimpactofstressreductionprogramsuponambulatorybloodpressureamongafricanamericanadolescentsinfluencesofendothelin1geneandchronicstressexposure |