Targeting Acetylcholinesterase: Identification of Chemical Leads by High Throughput Screening, Structure Determination and Molecular Modeling

Acetylcholinesterase (AChE) is an essential enzyme that terminates cholinergic transmission by rapid hydrolysis of the neurotransmitter acetylcholine. Compounds inhibiting this enzyme can be used (inter alia) to treat cholinergic deficiencies (e.g. in Alzheimer's disease), but may also act as d...

Descripción completa

Detalles Bibliográficos
Autores principales: Berg, Lotta, Andersson, C. David, Artursson, Elisabet, Hörnberg, Andreas, Tunemalm, Anna-Karin, Linusson, Anna, Ekström, Fredrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227566/
https://www.ncbi.nlm.nih.gov/pubmed/22140425
http://dx.doi.org/10.1371/journal.pone.0026039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227566/
https://www.ncbi.nlm.nih.gov/pubmed/22140425
http://dx.doi.org/10.1371/journal.pone.0026039

Ejemplares similares