Cargando…

Personality Is Reflected in the Brain's Intrinsic Functional Architecture

Personality describes persistent human behavioral responses to broad classes of environmental stimuli. Investigating how personality traits are reflected in the brain's functional architecture is challenging, in part due to the difficulty of designing appropriate task probes. Resting-state func...

Descripción completa

Detalles Bibliográficos
Autores principales: Adelstein, Jonathan S., Shehzad, Zarrar, Mennes, Maarten, DeYoung, Colin G., Zuo, Xi-Nian, Kelly, Clare, Margulies, Daniel S., Bloomfield, Aaron, Gray, Jeremy R., Castellanos, F. Xavier, Milham, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227579/
https://www.ncbi.nlm.nih.gov/pubmed/22140453
http://dx.doi.org/10.1371/journal.pone.0027633
_version_ 1782217760013549568
author Adelstein, Jonathan S.
Shehzad, Zarrar
Mennes, Maarten
DeYoung, Colin G.
Zuo, Xi-Nian
Kelly, Clare
Margulies, Daniel S.
Bloomfield, Aaron
Gray, Jeremy R.
Castellanos, F. Xavier
Milham, Michael P.
author_facet Adelstein, Jonathan S.
Shehzad, Zarrar
Mennes, Maarten
DeYoung, Colin G.
Zuo, Xi-Nian
Kelly, Clare
Margulies, Daniel S.
Bloomfield, Aaron
Gray, Jeremy R.
Castellanos, F. Xavier
Milham, Michael P.
author_sort Adelstein, Jonathan S.
collection PubMed
description Personality describes persistent human behavioral responses to broad classes of environmental stimuli. Investigating how personality traits are reflected in the brain's functional architecture is challenging, in part due to the difficulty of designing appropriate task probes. Resting-state functional connectivity (RSFC) can detect intrinsic activation patterns without relying on any specific task. Here we use RSFC to investigate the neural correlates of the five-factor personality domains. Based on seed regions placed within two cognitive and affective ‘hubs’ in the brain—the anterior cingulate and precuneus—each domain of personality predicted RSFC with a unique pattern of brain regions. These patterns corresponded with functional subdivisions responsible for cognitive and affective processing such as motivation, empathy and future-oriented thinking. Neuroticism and Extraversion, the two most widely studied of the five constructs, predicted connectivity between seed regions and the dorsomedial prefrontal cortex and lateral paralimbic regions, respectively. These areas are associated with emotional regulation, self-evaluation and reward, consistent with the trait qualities. Personality traits were mostly associated with functional connections that were inconsistently present across participants. This suggests that although a fundamental, core functional architecture is preserved across individuals, variable connections outside of that core encompass the inter-individual differences in personality that motivate diverse responses.
format Online
Article
Text
id pubmed-3227579
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-32275792011-12-02 Personality Is Reflected in the Brain's Intrinsic Functional Architecture Adelstein, Jonathan S. Shehzad, Zarrar Mennes, Maarten DeYoung, Colin G. Zuo, Xi-Nian Kelly, Clare Margulies, Daniel S. Bloomfield, Aaron Gray, Jeremy R. Castellanos, F. Xavier Milham, Michael P. PLoS One Research Article Personality describes persistent human behavioral responses to broad classes of environmental stimuli. Investigating how personality traits are reflected in the brain's functional architecture is challenging, in part due to the difficulty of designing appropriate task probes. Resting-state functional connectivity (RSFC) can detect intrinsic activation patterns without relying on any specific task. Here we use RSFC to investigate the neural correlates of the five-factor personality domains. Based on seed regions placed within two cognitive and affective ‘hubs’ in the brain—the anterior cingulate and precuneus—each domain of personality predicted RSFC with a unique pattern of brain regions. These patterns corresponded with functional subdivisions responsible for cognitive and affective processing such as motivation, empathy and future-oriented thinking. Neuroticism and Extraversion, the two most widely studied of the five constructs, predicted connectivity between seed regions and the dorsomedial prefrontal cortex and lateral paralimbic regions, respectively. These areas are associated with emotional regulation, self-evaluation and reward, consistent with the trait qualities. Personality traits were mostly associated with functional connections that were inconsistently present across participants. This suggests that although a fundamental, core functional architecture is preserved across individuals, variable connections outside of that core encompass the inter-individual differences in personality that motivate diverse responses. Public Library of Science 2011-11-30 /pmc/articles/PMC3227579/ /pubmed/22140453 http://dx.doi.org/10.1371/journal.pone.0027633 Text en Adelstein et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Adelstein, Jonathan S.
Shehzad, Zarrar
Mennes, Maarten
DeYoung, Colin G.
Zuo, Xi-Nian
Kelly, Clare
Margulies, Daniel S.
Bloomfield, Aaron
Gray, Jeremy R.
Castellanos, F. Xavier
Milham, Michael P.
Personality Is Reflected in the Brain's Intrinsic Functional Architecture
title Personality Is Reflected in the Brain's Intrinsic Functional Architecture
title_full Personality Is Reflected in the Brain's Intrinsic Functional Architecture
title_fullStr Personality Is Reflected in the Brain's Intrinsic Functional Architecture
title_full_unstemmed Personality Is Reflected in the Brain's Intrinsic Functional Architecture
title_short Personality Is Reflected in the Brain's Intrinsic Functional Architecture
title_sort personality is reflected in the brain's intrinsic functional architecture
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227579/
https://www.ncbi.nlm.nih.gov/pubmed/22140453
http://dx.doi.org/10.1371/journal.pone.0027633
work_keys_str_mv AT adelsteinjonathans personalityisreflectedinthebrainsintrinsicfunctionalarchitecture
AT shehzadzarrar personalityisreflectedinthebrainsintrinsicfunctionalarchitecture
AT mennesmaarten personalityisreflectedinthebrainsintrinsicfunctionalarchitecture
AT deyoungcoling personalityisreflectedinthebrainsintrinsicfunctionalarchitecture
AT zuoxinian personalityisreflectedinthebrainsintrinsicfunctionalarchitecture
AT kellyclare personalityisreflectedinthebrainsintrinsicfunctionalarchitecture
AT marguliesdaniels personalityisreflectedinthebrainsintrinsicfunctionalarchitecture
AT bloomfieldaaron personalityisreflectedinthebrainsintrinsicfunctionalarchitecture
AT grayjeremyr personalityisreflectedinthebrainsintrinsicfunctionalarchitecture
AT castellanosfxavier personalityisreflectedinthebrainsintrinsicfunctionalarchitecture
AT milhammichaelp personalityisreflectedinthebrainsintrinsicfunctionalarchitecture