Cargando…
Generation and characterization of transgenic mice expressing mitochondrial targeted red fluorescent protein selectively in neurons: modeling mitochondriopathy in excitotoxicity and amyotrophic lateral sclerosis
BACKGROUND: Mitochondria have roles or appear to have roles in the pathogenesis of several chronic age-related and acute neurological disorders, including Charcot-Marie-Tooth disease, amyotrophic lateral sclerosis, Parkinson's disease, and cerebral ischemia, and could be critical targets for de...
Autores principales: | Wang, Yi, Pan, Yan, Price, Ann, Martin, Lee J |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227596/ https://www.ncbi.nlm.nih.gov/pubmed/22047141 http://dx.doi.org/10.1186/1750-1326-6-75 |
Ejemplares similares
-
Mitochondrial Medicine and the Neurodegenerative Mitochondriopathies
por: Swerdlow, Russell H.
Publicado: (2009) -
The Key Role of Astrocytes in Amyotrophic Lateral Sclerosis and Their Commitment to Glutamate Excitotoxicity
por: Provenzano, Francesca, et al.
Publicado: (2023) -
Identifying the primary site of pathogenesis in amyotrophic lateral sclerosis – vulnerability of lower motor neurons to proximal excitotoxicity
por: Blizzard, Catherine A., et al.
Publicado: (2015) -
Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral sclerosis is developmentally regulated
por: Singh, Tanisha, et al.
Publicado: (2021) -
Riluzole But Not Melatonin Ameliorates Acute Motor Neuron Degeneration and Moderately Inhibits SOD1-Mediated Excitotoxicity Induced Disrupted Mitochondrial Ca(2+) Signaling in Amyotrophic Lateral Sclerosis
por: Jaiswal, Manoj Kumar
Publicado: (2017)