A Genetic Signature of Spina Bifida Risk from Pathway-Informed Comprehensive Gene-Variant Analysis

Despite compelling epidemiological evidence that folic acid supplements reduce the frequency of neural tube defects (NTDs) in newborns, common variant association studies with folate metabolism genes have failed to explain the majority of NTD risk. The contribution of rare alleles as well as genetic...

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Detalles Bibliográficos
Autores principales: Marini, Nicholas J., Hoffmann, Thomas J., Lammer, Edward J., Hardin, Jill, Lazaruk, Katherine, Stein, Jason B., Gilbert, Dennis A., Wright, Crystal, Lipzen, Anna, Pennacchio, Len A., Carmichael, Suzan L., Witte, John S., Shaw, Gary M., Rine, Jasper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227667/
https://www.ncbi.nlm.nih.gov/pubmed/22140583
http://dx.doi.org/10.1371/journal.pone.0028408

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