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A Systematic Analysis of the 3′UTR of HNF4A mRNA Reveals an Interplay of Regulatory Elements Including miRNA Target Sites

Dysfunction of hepatocyte nuclear factor 4α (HNF4α) has been linked to maturity onset diabetes of the young (MODY1), diabetes type II and possibly to renal cell carcinoma (RCC). Whereas diabetes causing mutations are well known, there are no HNF4A mutations found in RCC. Since so far analyses have b...

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Detalles Bibliográficos
Autores principales:	Wirsing, Andrea, Senkel, Sabine, Klein-Hitpass, Ludger, Ryffel, Gerhart U.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227676/ https://www.ncbi.nlm.nih.gov/pubmed/22140441 http://dx.doi.org/10.1371/journal.pone.0027438

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