The JAK2V617F oncogene requires expression of inducible phosphofructokinase/fructose-bisphosphatase 3 for cell growth and increased metabolic activity

Myeloproliferative neoplasms (MPNs) are characterized by overproduction of myeloid lineage cells with frequent acquisition of oncogenic JAK2V617F kinase mutations. The molecular mechanisms that regulate energy requirements in these diseases are poorly understood. Transformed cells tend to rely on fe...

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Detalles Bibliográficos
Autores principales: Reddy, Mamatha M., Fernandes, Margret S., Deshpande, Anagha, Weisberg, Ellen, Inguilizian, Haig V., Abdel-Wahab, Omar, Kung, Andrew L., Levine, Ross L., Griffin, James D., Sattler, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227767/
https://www.ncbi.nlm.nih.gov/pubmed/21860432
http://dx.doi.org/10.1038/leu.2011.225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227767/
https://www.ncbi.nlm.nih.gov/pubmed/21860432
http://dx.doi.org/10.1038/leu.2011.225

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