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Radiation Recall with Anticancer Agents

Radiation recall is an acute inflammatory reaction confined to previously irradiated areas that can be triggered when chemotherapy agents are administered after radiotherapy. It remains a poorly understood phenomenon, but increased awareness may aid early diagnosis and appropriate management. A dive...

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Detalles Bibliográficos
Autores principales: Burris, Howard A., Hurtig, Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AlphaMed Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227903/
https://www.ncbi.nlm.nih.gov/pubmed/21045191
http://dx.doi.org/10.1634/theoncologist.2009-0090
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author Burris, Howard A.
Hurtig, Jane
author_facet Burris, Howard A.
Hurtig, Jane
author_sort Burris, Howard A.
collection PubMed
description Radiation recall is an acute inflammatory reaction confined to previously irradiated areas that can be triggered when chemotherapy agents are administered after radiotherapy. It remains a poorly understood phenomenon, but increased awareness may aid early diagnosis and appropriate management. A diverse range of drugs used in the treatment of cancer has been associated with radiation recall. As most data come from case reports, it is not possible to determine the true incidence, but to date the antineoplastic drugs for which radiation recall reactions have been most commonly reported include the anthracycline doxorubicin, the taxanes docetaxel and paclitaxel, and the antimetabolites gemcitabine and capecitabine. Radiation recall is drug-specific for any individual patient; it is not possible to predict which patients will react to which drugs, and rechallenge does not uniformly induce a reaction. There are no identifiable characteristics of drugs that cause radiation recall, and thus, it is a possibility that must be kept in mind with use of any drug after radiotherapy, including those from new drug classes. Although it is not yet possible to design treatment regimens to eliminate the risk of radiation recall, it seems likely that risks can be minimized by prolonging the interval between completion of radiotherapy and initiation of chemotherapy.
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spelling pubmed-32279032012-04-25 Radiation Recall with Anticancer Agents Burris, Howard A. Hurtig, Jane Oncologist Radiation Oncology Radiation recall is an acute inflammatory reaction confined to previously irradiated areas that can be triggered when chemotherapy agents are administered after radiotherapy. It remains a poorly understood phenomenon, but increased awareness may aid early diagnosis and appropriate management. A diverse range of drugs used in the treatment of cancer has been associated with radiation recall. As most data come from case reports, it is not possible to determine the true incidence, but to date the antineoplastic drugs for which radiation recall reactions have been most commonly reported include the anthracycline doxorubicin, the taxanes docetaxel and paclitaxel, and the antimetabolites gemcitabine and capecitabine. Radiation recall is drug-specific for any individual patient; it is not possible to predict which patients will react to which drugs, and rechallenge does not uniformly induce a reaction. There are no identifiable characteristics of drugs that cause radiation recall, and thus, it is a possibility that must be kept in mind with use of any drug after radiotherapy, including those from new drug classes. Although it is not yet possible to design treatment regimens to eliminate the risk of radiation recall, it seems likely that risks can be minimized by prolonging the interval between completion of radiotherapy and initiation of chemotherapy. AlphaMed Press 2010-11 2010-11-02 /pmc/articles/PMC3227903/ /pubmed/21045191 http://dx.doi.org/10.1634/theoncologist.2009-0090 Text en ©AlphaMed Press available online without subscription through the open access option.
spellingShingle Radiation Oncology
Burris, Howard A.
Hurtig, Jane
Radiation Recall with Anticancer Agents
title Radiation Recall with Anticancer Agents
title_full Radiation Recall with Anticancer Agents
title_fullStr Radiation Recall with Anticancer Agents
title_full_unstemmed Radiation Recall with Anticancer Agents
title_short Radiation Recall with Anticancer Agents
title_sort radiation recall with anticancer agents
topic Radiation Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227903/
https://www.ncbi.nlm.nih.gov/pubmed/21045191
http://dx.doi.org/10.1634/theoncologist.2009-0090
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