Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 Cases

Management of patients with KPC-harboring Enterobacteriaceae has become a significant and challenging scenario. We report three cases of KPC-producing Klebsiella pneumoniae bacteremia that were successfully treated using combination therapy with polymyxin B and other antimicrobials. Serum bactericid...

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Detalles Bibliográficos
Autores principales: Gomez, Eric, Sanchez, Martha, Gul, Zonaira, Urban, Carl, Mariano, Noriel, Eng, Robert H. K., Huang, David B., Chiang, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228238/
https://www.ncbi.nlm.nih.gov/pubmed/22162703
http://dx.doi.org/10.1155/2011/659769
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author Gomez, Eric
Sanchez, Martha
Gul, Zonaira
Urban, Carl
Mariano, Noriel
Eng, Robert H. K.
Huang, David B.
Chiang, Tom
author_facet Gomez, Eric
Sanchez, Martha
Gul, Zonaira
Urban, Carl
Mariano, Noriel
Eng, Robert H. K.
Huang, David B.
Chiang, Tom
author_sort Gomez, Eric
collection PubMed
description Management of patients with KPC-harboring Enterobacteriaceae has become a significant and challenging scenario. We report three cases of KPC-producing Klebsiella pneumoniae bacteremia that were successfully treated using combination therapy with polymyxin B and other antimicrobials. Serum bactericidal titers were determined and provided additional clinical guidance in the management of such patients.
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spelling pubmed-32282382011-12-08 Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 Cases Gomez, Eric Sanchez, Martha Gul, Zonaira Urban, Carl Mariano, Noriel Eng, Robert H. K. Huang, David B. Chiang, Tom Case Rep Med Case Report Management of patients with KPC-harboring Enterobacteriaceae has become a significant and challenging scenario. We report three cases of KPC-producing Klebsiella pneumoniae bacteremia that were successfully treated using combination therapy with polymyxin B and other antimicrobials. Serum bactericidal titers were determined and provided additional clinical guidance in the management of such patients. Hindawi Publishing Corporation 2011 2011-11-28 /pmc/articles/PMC3228238/ /pubmed/22162703 http://dx.doi.org/10.1155/2011/659769 Text en Copyright © 2011 Eric Gomez et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Gomez, Eric
Sanchez, Martha
Gul, Zonaira
Urban, Carl
Mariano, Noriel
Eng, Robert H. K.
Huang, David B.
Chiang, Tom
Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 Cases
title Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 Cases
title_full Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 Cases
title_fullStr Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 Cases
title_full_unstemmed Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 Cases
title_short Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 Cases
title_sort polymyxin combination therapy and the use of serum bactericidal titers in the management of kpc-producing klebsiella pneumoniae infections: a report of 3 cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228238/
https://www.ncbi.nlm.nih.gov/pubmed/22162703
http://dx.doi.org/10.1155/2011/659769
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