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L-Carnitine Improves the Asthma Control in Children with Moderate Persistent Asthma

The objective. was to investigate L-Carnitine level and the effects of its supplementation in children with moderate persistent Asthma. Methods. Free and total serum carnitine levels were measured in 50 children having moderate persistent asthma and 50 healthy control children. The patients group wa...

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Autores principales: Al-Biltagi, Mohammed, Isa, Mona, Bediwy, Adel Salah, Helaly, Nevien, El Lebedy, Dalia D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228305/
https://www.ncbi.nlm.nih.gov/pubmed/22162707
http://dx.doi.org/10.1155/2012/509730
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author Al-Biltagi, Mohammed
Isa, Mona
Bediwy, Adel Salah
Helaly, Nevien
El Lebedy, Dalia D.
author_facet Al-Biltagi, Mohammed
Isa, Mona
Bediwy, Adel Salah
Helaly, Nevien
El Lebedy, Dalia D.
author_sort Al-Biltagi, Mohammed
collection PubMed
description The objective. was to investigate L-Carnitine level and the effects of its supplementation in children with moderate persistent Asthma. Methods. Free and total serum carnitine levels were measured in 50 children having moderate persistent asthma and 50 healthy control children. The patients group was randomly divided into two subgroups. Subgroup A was supplemented with L-carnitine for 6 months while subgroup B was used as a placebo controls. Both subgroups were assessed by pulmonary function tests (PFT) and childhood-asthma control test (C-ACT) before and 6 months after carnitine supplementation. Results. Total and free carnitine levels were significantly lower in patient group than in control group. PFT and C-ACT showed significant improvements in asthmatic children supplemented with L-carnitine than in those who were not supplemented. Conclusion. L-carnitine levels were initially lower in moderate persistent asthmatic children as compared to healthy control children. Asthmatic children who received L-carnitine supplementation showed statistically significant improvement of C-ACT and PFT.
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spelling pubmed-32283052011-12-08 L-Carnitine Improves the Asthma Control in Children with Moderate Persistent Asthma Al-Biltagi, Mohammed Isa, Mona Bediwy, Adel Salah Helaly, Nevien El Lebedy, Dalia D. J Allergy (Cairo) Research Article The objective. was to investigate L-Carnitine level and the effects of its supplementation in children with moderate persistent Asthma. Methods. Free and total serum carnitine levels were measured in 50 children having moderate persistent asthma and 50 healthy control children. The patients group was randomly divided into two subgroups. Subgroup A was supplemented with L-carnitine for 6 months while subgroup B was used as a placebo controls. Both subgroups were assessed by pulmonary function tests (PFT) and childhood-asthma control test (C-ACT) before and 6 months after carnitine supplementation. Results. Total and free carnitine levels were significantly lower in patient group than in control group. PFT and C-ACT showed significant improvements in asthmatic children supplemented with L-carnitine than in those who were not supplemented. Conclusion. L-carnitine levels were initially lower in moderate persistent asthmatic children as compared to healthy control children. Asthmatic children who received L-carnitine supplementation showed statistically significant improvement of C-ACT and PFT. Hindawi Publishing Corporation 2012 2011-11-23 /pmc/articles/PMC3228305/ /pubmed/22162707 http://dx.doi.org/10.1155/2012/509730 Text en Copyright © 2012 Mohammed Al-Biltagi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Al-Biltagi, Mohammed
Isa, Mona
Bediwy, Adel Salah
Helaly, Nevien
El Lebedy, Dalia D.
L-Carnitine Improves the Asthma Control in Children with Moderate Persistent Asthma
title L-Carnitine Improves the Asthma Control in Children with Moderate Persistent Asthma
title_full L-Carnitine Improves the Asthma Control in Children with Moderate Persistent Asthma
title_fullStr L-Carnitine Improves the Asthma Control in Children with Moderate Persistent Asthma
title_full_unstemmed L-Carnitine Improves the Asthma Control in Children with Moderate Persistent Asthma
title_short L-Carnitine Improves the Asthma Control in Children with Moderate Persistent Asthma
title_sort l-carnitine improves the asthma control in children with moderate persistent asthma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228305/
https://www.ncbi.nlm.nih.gov/pubmed/22162707
http://dx.doi.org/10.1155/2012/509730
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