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Unraveling the Design Principle for Motif Organization in Signaling Networks

Cellular signaling networks display complex architecture. Defining the design principle of this architecture is crucial for our understanding of various biological processes. Using a mathematical model for three-node feed-forward loops, we identify that the organization of motifs in specific manner...

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Detalles Bibliográficos
Autores principales: Chatterjee, Samrat, Kumar, Dhiraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228783/
https://www.ncbi.nlm.nih.gov/pubmed/22164309
http://dx.doi.org/10.1371/journal.pone.0028606
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author Chatterjee, Samrat
Kumar, Dhiraj
author_facet Chatterjee, Samrat
Kumar, Dhiraj
author_sort Chatterjee, Samrat
collection PubMed
description Cellular signaling networks display complex architecture. Defining the design principle of this architecture is crucial for our understanding of various biological processes. Using a mathematical model for three-node feed-forward loops, we identify that the organization of motifs in specific manner within the network serves as an important regulator of signal processing. Further, incorporating a systemic stochastic perturbation to the model we could propose a possible design principle, for higher-order organization of motifs into larger networks in order to achieve specific biological output. The design principle was then verified in a large, complex human cancer signaling network. Further analysis permitted us to classify signaling nodes of the network into robust and vulnerable nodes as a result of higher order motif organization. We show that distribution of these nodes within the network at strategic locations then provides for the range of features displayed by the signaling network.
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spelling pubmed-32287832011-12-07 Unraveling the Design Principle for Motif Organization in Signaling Networks Chatterjee, Samrat Kumar, Dhiraj PLoS One Research Article Cellular signaling networks display complex architecture. Defining the design principle of this architecture is crucial for our understanding of various biological processes. Using a mathematical model for three-node feed-forward loops, we identify that the organization of motifs in specific manner within the network serves as an important regulator of signal processing. Further, incorporating a systemic stochastic perturbation to the model we could propose a possible design principle, for higher-order organization of motifs into larger networks in order to achieve specific biological output. The design principle was then verified in a large, complex human cancer signaling network. Further analysis permitted us to classify signaling nodes of the network into robust and vulnerable nodes as a result of higher order motif organization. We show that distribution of these nodes within the network at strategic locations then provides for the range of features displayed by the signaling network. Public Library of Science 2011-12-02 /pmc/articles/PMC3228783/ /pubmed/22164309 http://dx.doi.org/10.1371/journal.pone.0028606 Text en Chatterjee, Kumar. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Chatterjee, Samrat
Kumar, Dhiraj
Unraveling the Design Principle for Motif Organization in Signaling Networks
title Unraveling the Design Principle for Motif Organization in Signaling Networks
title_full Unraveling the Design Principle for Motif Organization in Signaling Networks
title_fullStr Unraveling the Design Principle for Motif Organization in Signaling Networks
title_full_unstemmed Unraveling the Design Principle for Motif Organization in Signaling Networks
title_short Unraveling the Design Principle for Motif Organization in Signaling Networks
title_sort unraveling the design principle for motif organization in signaling networks
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228783/
https://www.ncbi.nlm.nih.gov/pubmed/22164309
http://dx.doi.org/10.1371/journal.pone.0028606
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