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Estimated Comparative Integration Hotspots Identify Different Behaviors of Retroviral Gene Transfer Vectors

Integration of retroviral vectors in the human genome follows non random patterns that favor insertional deregulation of gene expression and may cause risks of insertional mutagenesis when used in clinical gene therapy. Understanding how viral vectors integrate into the human genome is a key issue i...

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Detalles Bibliográficos
Autores principales:	Ambrosi, Alessandro, Glad, Ingrid K., Pellin, Danilo, Cattoglio, Claudia, Mavilio, Fulvio, Di Serio, Clelia, Frigessi, Arnoldo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228801/ https://www.ncbi.nlm.nih.gov/pubmed/22144885 http://dx.doi.org/10.1371/journal.pcbi.1002292

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