Follicular Dendritic Cell-Specific Prion Protein (PrP(c)) Expression Alone Is Sufficient to Sustain Prion Infection in the Spleen

Prion diseases are characterised by the accumulation of PrP(Sc), an abnormally folded isoform of the cellular prion protein (PrP(C)), in affected tissues. Following peripheral exposure high levels of prion-specific PrP(Sc) accumulate first upon follicular dendritic cells (FDC) in lymphoid tissues be...

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Detalles Bibliográficos
Autores principales: McCulloch, Laura, Brown, Karen L., Bradford, Barry M., Hopkins, John, Bailey, Mick, Rajewsky, Klaus, Manson, Jean C., Mabbott, Neil A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228802/
https://www.ncbi.nlm.nih.gov/pubmed/22144895
http://dx.doi.org/10.1371/journal.ppat.1002402

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