New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation

The red seaweed Laurencia viridis is a rich source of secondary metabolites derived from squalene. New polyethers, such as iubol (2), 22-hydroxy-15(28)- dehydrovenustatriol (3), 1,2-dehydropseudodehydrothyrsiferol (4), and secodehydrothyrsiferol (5) have been isolated and characterized from this alg...

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Autores principales: Pacheco, Francisco Cen, Villa-Pulgarin, Janny A., Mollinedo, Faustino, Martín, Manuel Norte, Fernández, José Javier, Daranas, Antonio Hernández
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229232/
https://www.ncbi.nlm.nih.gov/pubmed/22163183
http://dx.doi.org/10.3390/md9112220
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author Pacheco, Francisco Cen
Villa-Pulgarin, Janny A.
Mollinedo, Faustino
Martín, Manuel Norte
Fernández, José Javier
Daranas, Antonio Hernández
author_facet Pacheco, Francisco Cen
Villa-Pulgarin, Janny A.
Mollinedo, Faustino
Martín, Manuel Norte
Fernández, José Javier
Daranas, Antonio Hernández
author_sort Pacheco, Francisco Cen
collection PubMed
description The red seaweed Laurencia viridis is a rich source of secondary metabolites derived from squalene. New polyethers, such as iubol (2), 22-hydroxy-15(28)- dehydrovenustatriol (3), 1,2-dehydropseudodehydrothyrsiferol (4), and secodehydrothyrsiferol (5) have been isolated and characterized from this alga. The structures were determined through the interpretation of NMR spectroscopic data and the relative configuration was proposed on the basis of NOESY spectrum and biogenetic considerations. All new compounds exhibited significant cytotoxic activity against a panel of cancer cell lines.
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spelling pubmed-32292322011-12-12 New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation Pacheco, Francisco Cen Villa-Pulgarin, Janny A. Mollinedo, Faustino Martín, Manuel Norte Fernández, José Javier Daranas, Antonio Hernández Mar Drugs Article The red seaweed Laurencia viridis is a rich source of secondary metabolites derived from squalene. New polyethers, such as iubol (2), 22-hydroxy-15(28)- dehydrovenustatriol (3), 1,2-dehydropseudodehydrothyrsiferol (4), and secodehydrothyrsiferol (5) have been isolated and characterized from this alga. The structures were determined through the interpretation of NMR spectroscopic data and the relative configuration was proposed on the basis of NOESY spectrum and biogenetic considerations. All new compounds exhibited significant cytotoxic activity against a panel of cancer cell lines. Molecular Diversity Preservation International 2011-11-07 /pmc/articles/PMC3229232/ /pubmed/22163183 http://dx.doi.org/10.3390/md9112220 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Pacheco, Francisco Cen
Villa-Pulgarin, Janny A.
Mollinedo, Faustino
Martín, Manuel Norte
Fernández, José Javier
Daranas, Antonio Hernández
New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation
title New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation
title_full New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation
title_fullStr New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation
title_full_unstemmed New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation
title_short New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation
title_sort new polyether triterpenoids from laurencia viridis and their biological evaluation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229232/
https://www.ncbi.nlm.nih.gov/pubmed/22163183
http://dx.doi.org/10.3390/md9112220
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