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Advancement into the Arctic Region for Bioactive Sponge Secondary Metabolites

Porifera have long been a reservoir for the discovery of bioactive compounds and drug discovery. Most research in the area has focused on sponges from tropical and temperate waters, but more recently the focus has shifted to the less accessible colder waters of the Antarctic and, to a lesser extent,...

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Detalles Bibliográficos
Autores principales: Abbas, Samuel, Kelly, Michelle, Bowling, John, Sims, James, Waters, Amanda, Hamann, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229243/
https://www.ncbi.nlm.nih.gov/pubmed/22163194
http://dx.doi.org/10.3390/md9112423
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author Abbas, Samuel
Kelly, Michelle
Bowling, John
Sims, James
Waters, Amanda
Hamann, Mark
author_facet Abbas, Samuel
Kelly, Michelle
Bowling, John
Sims, James
Waters, Amanda
Hamann, Mark
author_sort Abbas, Samuel
collection PubMed
description Porifera have long been a reservoir for the discovery of bioactive compounds and drug discovery. Most research in the area has focused on sponges from tropical and temperate waters, but more recently the focus has shifted to the less accessible colder waters of the Antarctic and, to a lesser extent, the Arctic. The Antarctic region in particular has been a more popular location for natural products discovery and has provided promising candidates for drug development. This article reviews groups of bioactive compounds that have been isolated and reported from the southern reaches of the Arctic Circle, surveys the known sponge diversity present in the Arctic waters, and details a recent sponge collection by our group in the Aleutian Islands, Alaska. The collection has yielded previously undescribed sponge species along with primary activity against opportunistic infectious diseases, malaria, and HCV. The discovery of new sponge species and bioactive crude extracts gives optimism for the isolation of new bioactive compounds from a relatively unexplored source.
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spelling pubmed-32292432011-12-12 Advancement into the Arctic Region for Bioactive Sponge Secondary Metabolites Abbas, Samuel Kelly, Michelle Bowling, John Sims, James Waters, Amanda Hamann, Mark Mar Drugs Review Porifera have long been a reservoir for the discovery of bioactive compounds and drug discovery. Most research in the area has focused on sponges from tropical and temperate waters, but more recently the focus has shifted to the less accessible colder waters of the Antarctic and, to a lesser extent, the Arctic. The Antarctic region in particular has been a more popular location for natural products discovery and has provided promising candidates for drug development. This article reviews groups of bioactive compounds that have been isolated and reported from the southern reaches of the Arctic Circle, surveys the known sponge diversity present in the Arctic waters, and details a recent sponge collection by our group in the Aleutian Islands, Alaska. The collection has yielded previously undescribed sponge species along with primary activity against opportunistic infectious diseases, malaria, and HCV. The discovery of new sponge species and bioactive crude extracts gives optimism for the isolation of new bioactive compounds from a relatively unexplored source. Molecular Diversity Preservation International 2011-11-21 /pmc/articles/PMC3229243/ /pubmed/22163194 http://dx.doi.org/10.3390/md9112423 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Abbas, Samuel
Kelly, Michelle
Bowling, John
Sims, James
Waters, Amanda
Hamann, Mark
Advancement into the Arctic Region for Bioactive Sponge Secondary Metabolites
title Advancement into the Arctic Region for Bioactive Sponge Secondary Metabolites
title_full Advancement into the Arctic Region for Bioactive Sponge Secondary Metabolites
title_fullStr Advancement into the Arctic Region for Bioactive Sponge Secondary Metabolites
title_full_unstemmed Advancement into the Arctic Region for Bioactive Sponge Secondary Metabolites
title_short Advancement into the Arctic Region for Bioactive Sponge Secondary Metabolites
title_sort advancement into the arctic region for bioactive sponge secondary metabolites
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229243/
https://www.ncbi.nlm.nih.gov/pubmed/22163194
http://dx.doi.org/10.3390/md9112423
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