A New Diketopiperazine, Cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian Specimen of the Sponge Stelletta sp.

While investigating the cytotoxic activity of the methanol extract of an Australian marine sponge Stelletta sp. (Demospongiae), a new diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine) (1), was isolated together with the known bengamides; A (2), F (3), N (4), Y (5), and bengazoles; Z (6),...

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Autores principales: Ovenden, Simon P. B., Nielson, Jonathan L., Liptrot, Catherine H., Willis, Richard H., Tapiolas, Dianne M., Wright, Anthony D., Motti, Cherie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
Materias:
Short Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229245/
https://www.ncbi.nlm.nih.gov/pubmed/22163196
http://dx.doi.org/10.3390/md9112469
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author Ovenden, Simon P. B.
Nielson, Jonathan L.
Liptrot, Catherine H.
Willis, Richard H.
Tapiolas, Dianne M.
Wright, Anthony D.
Motti, Cherie A.
author_facet Ovenden, Simon P. B.
Nielson, Jonathan L.
Liptrot, Catherine H.
Willis, Richard H.
Tapiolas, Dianne M.
Wright, Anthony D.
Motti, Cherie A.
author_sort Ovenden, Simon P. B.
collection PubMed
description While investigating the cytotoxic activity of the methanol extract of an Australian marine sponge Stelletta sp. (Demospongiae), a new diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine) (1), was isolated together with the known bengamides; A (2), F (3), N (4), Y (5), and bengazoles; Z (6), C(4) (7) and C(6) (8). The isolation and structure elucidation of the diketopiperazine (1), together with the activity of 1–8 against a panel of human and mammalian cell lines are discussed.
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spelling pubmed-32292452011-12-12 A New Diketopiperazine, Cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian Specimen of the Sponge Stelletta sp. Ovenden, Simon P. B. Nielson, Jonathan L. Liptrot, Catherine H. Willis, Richard H. Tapiolas, Dianne M. Wright, Anthony D. Motti, Cherie A. Mar Drugs Short Note While investigating the cytotoxic activity of the methanol extract of an Australian marine sponge Stelletta sp. (Demospongiae), a new diketopiperazine, cyclo-(4-S-hydroxy-R-proline-R-isoleucine) (1), was isolated together with the known bengamides; A (2), F (3), N (4), Y (5), and bengazoles; Z (6), C(4) (7) and C(6) (8). The isolation and structure elucidation of the diketopiperazine (1), together with the activity of 1–8 against a panel of human and mammalian cell lines are discussed. Molecular Diversity Preservation International 2011-11-22 /pmc/articles/PMC3229245/ /pubmed/22163196 http://dx.doi.org/10.3390/md9112469 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Short Note
Ovenden, Simon P. B.
Nielson, Jonathan L.
Liptrot, Catherine H.
Willis, Richard H.
Tapiolas, Dianne M.
Wright, Anthony D.
Motti, Cherie A.
A New Diketopiperazine, Cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian Specimen of the Sponge Stelletta sp.
title A New Diketopiperazine, Cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian Specimen of the Sponge Stelletta sp.
title_full A New Diketopiperazine, Cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian Specimen of the Sponge Stelletta sp.
title_fullStr A New Diketopiperazine, Cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian Specimen of the Sponge Stelletta sp.
title_full_unstemmed A New Diketopiperazine, Cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian Specimen of the Sponge Stelletta sp.
title_short A New Diketopiperazine, Cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian Specimen of the Sponge Stelletta sp.
title_sort new diketopiperazine, cyclo-(4-s-hydroxy-r-proline-r-isoleucine), from an australian specimen of the sponge stelletta sp.
topic Short Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229245/
https://www.ncbi.nlm.nih.gov/pubmed/22163196
http://dx.doi.org/10.3390/md9112469
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