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Putting the pH into phosphatidic acid signaling
The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic regulation in all organisms. New evidence indicates that PA also has an unprecedented role as a pH biosensor, coupling changes in pH to intracellular signaling pathways. pH sensing is a property of the phosphomonoes...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229452/ https://www.ncbi.nlm.nih.gov/pubmed/22136116 http://dx.doi.org/10.1186/1741-7007-9-85 |
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| author | Shin, John JH Loewen, Christopher JR |
| author_facet | Shin, John JH Loewen, Christopher JR |
| author_sort | Shin, John JH |
| collection | PubMed |
| description | The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic regulation in all organisms. New evidence indicates that PA also has an unprecedented role as a pH biosensor, coupling changes in pH to intracellular signaling pathways. pH sensing is a property of the phosphomonoester headgroup of PA. A number of other potent signaling lipids also contain headgroups with phosphomonoesters, implying that pH sensing by lipids may be widespread in biology. |
| format | Online Article Text |
| id | pubmed-3229452 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2011 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-32294522011-12-03 Putting the pH into phosphatidic acid signaling Shin, John JH Loewen, Christopher JR BMC Biol Review The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic regulation in all organisms. New evidence indicates that PA also has an unprecedented role as a pH biosensor, coupling changes in pH to intracellular signaling pathways. pH sensing is a property of the phosphomonoester headgroup of PA. A number of other potent signaling lipids also contain headgroups with phosphomonoesters, implying that pH sensing by lipids may be widespread in biology. BioMed Central 2011-12-02 /pmc/articles/PMC3229452/ /pubmed/22136116 http://dx.doi.org/10.1186/1741-7007-9-85 Text en Copyright ©2011 Shin and Loewen; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Review Shin, John JH Loewen, Christopher JR Putting the pH into phosphatidic acid signaling |
| title | Putting the pH into phosphatidic acid signaling |
| title_full | Putting the pH into phosphatidic acid signaling |
| title_fullStr | Putting the pH into phosphatidic acid signaling |
| title_full_unstemmed | Putting the pH into phosphatidic acid signaling |
| title_short | Putting the pH into phosphatidic acid signaling |
| title_sort | putting the ph into phosphatidic acid signaling |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229452/ https://www.ncbi.nlm.nih.gov/pubmed/22136116 http://dx.doi.org/10.1186/1741-7007-9-85 |
| work_keys_str_mv | AT shinjohnjh puttingthephintophosphatidicacidsignaling AT loewenchristopherjr puttingthephintophosphatidicacidsignaling |