Aberrant Hedgehog Ligands Induce Progressive Pancreatic Fibrosis by Paracrine Activation of Myofibroblasts and Ductular Cells in Transgenic Zebrafish

Hedgehog (Hh) signaling is frequently up-regulated in fibrogenic pancreatic diseases including chronic pancreatitis and pancreatic cancer. Although recent series suggest exclusive paracrine activation of stromal cells by Hh ligands from epithelial components, debates still exist on how Hh signaling...

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Detalles Bibliográficos
Autores principales: Jung, In Hye, Jung, Dawoon E., Park, Young Nyun, Song, Si Young, Park, Seung Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229500/
https://www.ncbi.nlm.nih.gov/pubmed/22164219
http://dx.doi.org/10.1371/journal.pone.0027941

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