CASPASE 8 inhibits programmed necrosis by processing CYLD

CASPASE 8 initiates apoptosis downstream of TNF death receptors by undergoing autocleavage and processing the executioner CASPASE 3(1). However, the dominant function of CASPASE 8 is to transmit a pro-survival signal that suppresses programmed necrosis (or necroptosis) mediated by RIPK1 and RIPK3(2–...

Descripción completa

Detalles Bibliográficos
Autores principales: O’Donnell, Marie Anne, Perez-Jimenez, Eva, Oberst, Andrew, Ng, Aylwin, Massoumi, Ramin, Xavier, Ramnik, Green, Douglas R., Ting, Adrian T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229661/
https://www.ncbi.nlm.nih.gov/pubmed/22037414
http://dx.doi.org/10.1038/ncb2362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229661/
https://www.ncbi.nlm.nih.gov/pubmed/22037414
http://dx.doi.org/10.1038/ncb2362

Ejemplares similares