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CASPASE 8 inhibits programmed necrosis by processing CYLD

CASPASE 8 initiates apoptosis downstream of TNF death receptors by undergoing autocleavage and processing the executioner CASPASE 3(1). However, the dominant function of CASPASE 8 is to transmit a pro-survival signal that suppresses programmed necrosis (or necroptosis) mediated by RIPK1 and RIPK3(2–...

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Detalles Bibliográficos
Autores principales:	O’Donnell, Marie Anne, Perez-Jimenez, Eva, Oberst, Andrew, Ng, Aylwin, Massoumi, Ramin, Xavier, Ramnik, Green, Douglas R., Ting, Adrian T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229661/ https://www.ncbi.nlm.nih.gov/pubmed/22037414 http://dx.doi.org/10.1038/ncb2362

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