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Effect of Cryogrinding on Chemical Stability of the Sparingly Water-Soluble Drug Furosemide

PURPOSE: To investigate the effect of cryogrinding on chemical stability of the diuretic agent furosemide and its mixtures with selected excipients. METHODS: Furosemide was ground at liquid nitrogen temperature for 30, 60, 120 and 180 min. Mixtures of furosemide-PVP and furosemide-inulin (1:1) were...

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Detalles Bibliográficos
Autores principales:	Adrjanowicz, Karolina, Kaminski, Kamil, Grzybowska, Katarzyna, Hawelek, Lukasz, Paluch, Marian, Gruszka, Irena, Zakowiecki, Daniel, Sawicki, Wieslaw, Lepek, Przemyslaw, Kamysz, Wojciech, Guzik, Lukasz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2011
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229691/ https://www.ncbi.nlm.nih.gov/pubmed/21706267 http://dx.doi.org/10.1007/s11095-011-0496-4

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