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Vitamin-C as anti-Helicobacter pylori agent: More prophylactic than curative- Critical review

Potential of nonantibiotic therapies for treatment of Helicobacter pylori-related acid peptic disease remains underexplored. Several clinical studies have shown that higher prevalence of H. pylori infection is associated with low Vitamin C (Vit C) level in serum and gastric juice. However, there is...

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Autores principales: Pal, Jagannath, Sanal, Madhusudana Girija, Gopal, Gopal Jee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229773/
https://www.ncbi.nlm.nih.gov/pubmed/22144762
http://dx.doi.org/10.4103/0253-7613.89814
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author Pal, Jagannath
Sanal, Madhusudana Girija
Gopal, Gopal Jee
author_facet Pal, Jagannath
Sanal, Madhusudana Girija
Gopal, Gopal Jee
author_sort Pal, Jagannath
collection PubMed
description Potential of nonantibiotic therapies for treatment of Helicobacter pylori-related acid peptic disease remains underexplored. Several clinical studies have shown that higher prevalence of H. pylori infection is associated with low Vitamin C (Vit C) level in serum and gastric juice. However, there is no consensus regarding the usefulness of Vit C supplementation in the management of H. pylori infection. Surveying the existing literature we conclude that high concentration of Vit C in gastric juice might inactivate H. pylori urease, the key enzyme for the pathogen's survival and colonization into acidic stomach. Once infection established, urease is not very important for its survival. The role of Vit-C as anti-H. pylori agent in peptic ulcer diseases appears to be preventive rather than curative. Rather than supplementing high dose of Vit C along with conventional triple therapy, it is preferable to complete the conventional therapy and thereafter start Vit C supplementation for extended period which would prevent reinfection in susceptible individuals, provided the patients are not achlorhydric. Further studies are required to prove the role of Vit C in susceptible population.
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spelling pubmed-32297732011-12-05 Vitamin-C as anti-Helicobacter pylori agent: More prophylactic than curative- Critical review Pal, Jagannath Sanal, Madhusudana Girija Gopal, Gopal Jee Indian J Pharmacol Educational Forum Potential of nonantibiotic therapies for treatment of Helicobacter pylori-related acid peptic disease remains underexplored. Several clinical studies have shown that higher prevalence of H. pylori infection is associated with low Vitamin C (Vit C) level in serum and gastric juice. However, there is no consensus regarding the usefulness of Vit C supplementation in the management of H. pylori infection. Surveying the existing literature we conclude that high concentration of Vit C in gastric juice might inactivate H. pylori urease, the key enzyme for the pathogen's survival and colonization into acidic stomach. Once infection established, urease is not very important for its survival. The role of Vit-C as anti-H. pylori agent in peptic ulcer diseases appears to be preventive rather than curative. Rather than supplementing high dose of Vit C along with conventional triple therapy, it is preferable to complete the conventional therapy and thereafter start Vit C supplementation for extended period which would prevent reinfection in susceptible individuals, provided the patients are not achlorhydric. Further studies are required to prove the role of Vit C in susceptible population. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3229773/ /pubmed/22144762 http://dx.doi.org/10.4103/0253-7613.89814 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Educational Forum
Pal, Jagannath
Sanal, Madhusudana Girija
Gopal, Gopal Jee
Vitamin-C as anti-Helicobacter pylori agent: More prophylactic than curative- Critical review
title Vitamin-C as anti-Helicobacter pylori agent: More prophylactic than curative- Critical review
title_full Vitamin-C as anti-Helicobacter pylori agent: More prophylactic than curative- Critical review
title_fullStr Vitamin-C as anti-Helicobacter pylori agent: More prophylactic than curative- Critical review
title_full_unstemmed Vitamin-C as anti-Helicobacter pylori agent: More prophylactic than curative- Critical review
title_short Vitamin-C as anti-Helicobacter pylori agent: More prophylactic than curative- Critical review
title_sort vitamin-c as anti-helicobacter pylori agent: more prophylactic than curative- critical review
topic Educational Forum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229773/
https://www.ncbi.nlm.nih.gov/pubmed/22144762
http://dx.doi.org/10.4103/0253-7613.89814
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