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Development of a simple radiant heat induced experimental pain model for evaluation of analgesics in normal healthy human volunteers

OBJECTIVE: Human experimental pain models help to understand the mechanism of the painful conditions and can also be adopted to test analgesic efficacy of drugs. In early phases, the clinical development of new analgesics is hindered due to the lack of reliable tests for the experimental pain models...

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Autores principales: Naidu, M.U.R., Reddy, K. Sunil Kumar, Rani, P. Usha, Rao, T. Ramesh Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229775/
https://www.ncbi.nlm.nih.gov/pubmed/22144764
http://dx.doi.org/10.4103/0253-7613.89816
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author Naidu, M.U.R.
Reddy, K. Sunil Kumar
Rani, P. Usha
Rao, T. Ramesh Kumar
author_facet Naidu, M.U.R.
Reddy, K. Sunil Kumar
Rani, P. Usha
Rao, T. Ramesh Kumar
author_sort Naidu, M.U.R.
collection PubMed
description OBJECTIVE: Human experimental pain models help to understand the mechanism of the painful conditions and can also be adopted to test analgesic efficacy of drugs. In early phases, the clinical development of new analgesics is hindered due to the lack of reliable tests for the experimental pain models. In the present study, we have developed and validated a simple radiant heat pain model which can be used for future screening of various analgesic agents. MATERIALS AND METHODS: We have standardized the thermal pain model by recording pain threshold and pain tolerance time in seconds at three different intensities and levels in 24 healthy subjects. Reproducibility of the test procedure was evaluated by recording the pain parameters by two observers on three consecutive days. Validity of model was further tested by evaluating the analgesic effect of tramadol. RESULTS AND CONCLUSIONS: Use of radiant heat pain model with high intensity and short level was found to produce low variability with coefficient of variation less than 5%. Interobserver and interperiod reproducibility was very good as shown by Bland - Altman plot; with most of the values within ± 2SD. Tramadol produced statistically significant increase in pain threshold time. The newly developed pain model produces a type of experimental pain which is responsive to analgesic effects of tramadol at clinically relevant doses.
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spelling pubmed-32297752011-12-05 Development of a simple radiant heat induced experimental pain model for evaluation of analgesics in normal healthy human volunteers Naidu, M.U.R. Reddy, K. Sunil Kumar Rani, P. Usha Rao, T. Ramesh Kumar Indian J Pharmacol Research Article OBJECTIVE: Human experimental pain models help to understand the mechanism of the painful conditions and can also be adopted to test analgesic efficacy of drugs. In early phases, the clinical development of new analgesics is hindered due to the lack of reliable tests for the experimental pain models. In the present study, we have developed and validated a simple radiant heat pain model which can be used for future screening of various analgesic agents. MATERIALS AND METHODS: We have standardized the thermal pain model by recording pain threshold and pain tolerance time in seconds at three different intensities and levels in 24 healthy subjects. Reproducibility of the test procedure was evaluated by recording the pain parameters by two observers on three consecutive days. Validity of model was further tested by evaluating the analgesic effect of tramadol. RESULTS AND CONCLUSIONS: Use of radiant heat pain model with high intensity and short level was found to produce low variability with coefficient of variation less than 5%. Interobserver and interperiod reproducibility was very good as shown by Bland - Altman plot; with most of the values within ± 2SD. Tramadol produced statistically significant increase in pain threshold time. The newly developed pain model produces a type of experimental pain which is responsive to analgesic effects of tramadol at clinically relevant doses. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3229775/ /pubmed/22144764 http://dx.doi.org/10.4103/0253-7613.89816 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Naidu, M.U.R.
Reddy, K. Sunil Kumar
Rani, P. Usha
Rao, T. Ramesh Kumar
Development of a simple radiant heat induced experimental pain model for evaluation of analgesics in normal healthy human volunteers
title Development of a simple radiant heat induced experimental pain model for evaluation of analgesics in normal healthy human volunteers
title_full Development of a simple radiant heat induced experimental pain model for evaluation of analgesics in normal healthy human volunteers
title_fullStr Development of a simple radiant heat induced experimental pain model for evaluation of analgesics in normal healthy human volunteers
title_full_unstemmed Development of a simple radiant heat induced experimental pain model for evaluation of analgesics in normal healthy human volunteers
title_short Development of a simple radiant heat induced experimental pain model for evaluation of analgesics in normal healthy human volunteers
title_sort development of a simple radiant heat induced experimental pain model for evaluation of analgesics in normal healthy human volunteers
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229775/
https://www.ncbi.nlm.nih.gov/pubmed/22144764
http://dx.doi.org/10.4103/0253-7613.89816
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