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Subchronic treatment with fluoxetine attenuates the proerectile effect of Aspidosperma ulei Markgr (Apocyanaceae)

OBJECTIVE: To evaluate the ability of acute or chronic treatment with fluoxetine to alter the proerectile effect of Aspidosperma ulei alkaloid-rich fraction (F3-5). MATERIALS AND METHODS: In the first series of experiments, three groups of mice received either a single intraperitoneal injection of v...

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Detalles Bibliográficos
Autores principales: Campos, Adriana Rolim, de Andrade Uchôa, Daniel Esdras, Rocha, Edilberto Silveira, Martins da Costa, José Galberto, Rao, Vietla Satyanarayana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229790/
https://www.ncbi.nlm.nih.gov/pubmed/22144779
http://dx.doi.org/10.4103/0253-7613.89831
Descripción
Sumario:OBJECTIVE: To evaluate the ability of acute or chronic treatment with fluoxetine to alter the proerectile effect of Aspidosperma ulei alkaloid-rich fraction (F3-5). MATERIALS AND METHODS: In the first series of experiments, three groups of mice received either a single intraperitoneal injection of vehicle, F3-5 (25 mg/kg) or fluoxetine (10 mg/kg) + F3-5. Three behavioral responses were counted over a period of 30 min: erection, erection-like response and genital grooming. In a second series of experiments, animals treated for 13 days with fluoxetine or fluoxetine + F3-5 were assessed. RESULTS: A. ulei has been suggested to have proerectile effect in mice. Subchronic (13-d) treatment with fluoxetine resulted in a reduction in the number erections in F3-5-treated mice. CONCLUSION: Sexual dysfunction associated with antidepressant treatment continues to be a major compliance issue for antidepressant therapy. Acute administration of fluoxetine resulted in a near total reversal of the proerectile effect of F3-5.